溶洞源链霉菌FD-2-6中三个新的聚酮化合物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2026-04-18 Epub Date: 2025-02-01 DOI:10.1080/14786419.2025.2460103

Xuehao Hu , Xiu Yang , Liangqun Li , Lijuan Ge , Qiji Li , Xiaosheng Yang , Juan Yang , Ming Gao

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引用次数: 0

摘要

从溶洞源链霉菌（FD-2-6）的培养液中分离到3个新的聚酮，分别为放线素酮J(1)和K(2)、nocapyrone S(3)和1个已知化合物nocapyrone Q(4)。通过NMR、HR-MS和电子圆二色性（ECD）数据的综合分析，对它们的结构进行了鉴定。通过检测化合物1 ~ 4对MCF-7人乳腺癌细胞、人肝癌HepG2细胞、人宫颈癌Hela细胞和肺炎克雷伯菌、铜绿假单胞菌、污垢分枝杆菌、大肠杆菌、金黄色葡萄球菌的IC50和MIC值，研究化合物1 ~ 4对MCF-7人乳腺癌细胞的抑瘤抑菌活性。和人类宫颈癌的海拉细胞

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Three new polyketides isolated from the Karst cave-derived Streptomyces sp. FD-2-6

Three new polyketides, actinofuranones J (1) and K (2), nocapyrone S (3), with one known compound nocapyrone Q (4) were isolated from the culture broth of a Karst cave-derived Streptomyces sp. (FD-2-6). Their structures were elucidated by comprehensive analysis of NMR spectroscopic data, HR-MS and electronic circular dichroism (ECD) data. The antitumour and antibacterial activities of 1-4 were investigated by examining their IC₅₀ and MIC values in MCF-7 human breast cancer cells, human hepatocellular carcinoma HepG2 cells and human cervical cancer Hela cells, and Klebsiella pneumoniae sp, Pseudomonas aeruginosa sp, Mycolicibacterium smegmatis sp, Escherichia coli sp, Staphylococcus aureus sp. Compounds 1-4 showed weak inhibitory effect on antitumour activity on MCF-7 human breast cancer cells, and human cervical cancer Hela cells.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.