心源性猝死是心血管疾病的第一表现：一项涉及54,028例死亡的全国性研究

IF 8 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC. Clinical electrophysiology Pub Date : 2025-05-01 DOI:10.1016/j.jacep.2024.12.012

Tobias Skjelbred MD , Peder Emil Warming MD , Johanna Krøll MD , Mikkel Porsborg Andersen MScPH, PhD , Christian Torp-Pedersen MD, DMSc , Bo Gregers Winkel MD, PhD , Jacob Tfelt-Hansen MD, DMSc , Thomas Hadberg Lynge MD, PhD

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引用次数: 0

摘要

背景：心源性猝死（SCD）是一个重大的公共卫生问题。对无心血管疾病史的SCD患者的了解有限，这对未来的预防工作提出了挑战。目的：本研究旨在研究有和没有已知心血管疾病史的SCD病例之间的差异。方法：从2010年1月1日起，对所有丹麦公民进行随访，直至死亡或年底。在此期间，丹麦的所有死亡病例均由≥1名医生审查，以确定SCD病例。数据分析时间为2023年3月至2024年3月。结果：共发现6851例SCD，其中3046例（44.5%）无CVD病史。SCD的发病率随着年龄的增长而增加，在所有年龄组中，有心血管疾病史的患者发病率更高。有和没有心血管疾病史的个体之间的SCD发病率差异随着年龄的增长而降低，0 - 19岁人群的发病率比为21.6 (95% CI: 5.2-66.7)，而0 - 90岁人群的发病率比为1.8 （95% CI: 1.7-1.9）。女性和独居与SCD前患CVD的几率较低相关，or分别为0.66和0.75。结论：SCD病例的分布在有和没有CVD病史的个体之间几乎相等，尽管有CVD病史的个体的风险仍然较高。未来的研究应该旨在揭示在已知心血管疾病人群以及一般人群中驱动SCD的独特原因和机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sudden Cardiac Death as First Manifestation of Cardiovascular Disease

Background

Sudden cardiac death (SCD) is a significant public health problem. Knowledge on SCD victims without a history of cardiovascular disease (CVD) is limited, presenting challenges for future prevention efforts.

Objectives

This study aims to examine the differences between SCD cases with and without a known history of CVD.

Methods

All Danish citizens were followed from January 1, 2010, until death or the end of the year. All deaths in Denmark during this period were reviewed by ≥1 medical doctor to identify cases of SCD. Data were analyzed from March 2023 until March 2024.

Results

A total of 6,851 SCD cases were identified, of which 3,046 (44.5%) had no history of CVD. Incidence rates of SCD increased with age and were higher in cases with a history of CVD across all age groups. The difference in SCD incidence between individuals with and without a history of CVD decreased with age, with incidence rate ratios ranging from 21.6 (95% CI: 5.2-66.7) in those aged 0 to 19 years to 1.8 (95% CI: 1.7-1.9) in those aged >90 years. Female sex and living alone were associated with a lower odds of having a CVD before SCD with ORs of 0.66 and 0.75, respectively.

Conclusions

The distribution of SCD cases is nearly equal between individuals with and without a history of CVD, although the risk remains higher in those with prior CVD. Future research should aim to uncover the distinct causes and mechanisms driving SCD in populations with a known CVD, as well as the general population.

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来源期刊

JACC. Clinical electrophysiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

10.30

自引率

5.70%

发文量

250

期刊介绍： JACC: Clinical Electrophysiology is one of a family of specialist journals launched by the renowned Journal of the American College of Cardiology (JACC). It encompasses all aspects of the epidemiology, pathogenesis, diagnosis and treatment of cardiac arrhythmias. Submissions of original research and state-of-the-art reviews from cardiology, cardiovascular surgery, neurology, outcomes research, and related fields are encouraged. Experimental and preclinical work that directly relates to diagnostic or therapeutic interventions are also encouraged. In general, case reports will not be considered for publication.