瞳孔不安在注意缺陷多动障碍（ADHD）中减弱。

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2025-02-04 DOI:10.1016/j.neulet.2025.138148

Claudio M. Privitera , Sean Noah , Thom Carney , Stanley A. Klein , Agatha Lenartowicz , Stephen P. Hinshaw , James T. McCracken , Joel T. Nigg , Sarah L. Karalunas , Rory C. Reid , Mercedes Oliva , Samantha S. Betts , Gregory V. Simpson

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引用次数: 0

摘要

我们研究了注意缺陷多动障碍（ADHD）患者瞳孔不安的现象，并与神经正常对照进行了比较。我们在两种实验条件下测量了低频瞳孔振荡的功率：最小分心的被动条件和无分心的休息条件。该研究包括76名年龄在18-40岁的成年人（42名对照组和34名ADHD患者）。结果表明，患有ADHD的个体瞳孔振荡能力减弱，表明一般儿茶酚胺能活性受到抑制。实验的性质表明，这种抑制是在背景中特有的，独立于视觉任务或正在进行的认知努力。这一发现与我们之前的观察结果一致，即多动症患者在活动任务时瞳孔扩张缩小，为未来的研究提供了基本的见解，旨在开发和完善一种心理物理范式，作为一种生物标志物，可以增强多动症的评估和分类。

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Pupillary unrest is attenuated in attention deficit hyperactivity disorder (ADHD)

We investigated the phenomenon of pupillary unrest in individuals with Attention Deficit Hyperactivity Disorder (ADHD) compared to neurotypical controls. We measured the power of low-frequency pupil oscillations under two experimental conditions: a passive condition with minimal distraction and a resting condition with no distraction. The study included 76 adult participants (42 controls and 34 with ADHD) aged 18–40. The results show that individuals with ADHD exhibit reduced power in pupillary oscillations, suggesting a suppression of general catecholaminergic activity. The nature of the experiment indicates that this suppression is endemic in the background and independent of the visual task or the ongoing cognitive effort. This finding is consistent with our previous observations of reduced pupil dilations in ADHD during active tasks [1] and provide basic insights for future research aimed at developing and refining a psychophysical paradigm that could serve as a biomarker to enhance ADHD evaluation and classification.

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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