{"title":"共存的肥胖和营养不良及其对中风和脑结构的影响：来自英国生物银行研究的见解。","authors":"Yajun Li, Pan Zhang, Yingjie Xu, Jinghui Zhong, Miaomiao Hu, Wen Sun, BuChun Zhang","doi":"10.1159/000543819","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The dual burden of malnutrition, characterized by the coexistence of malnutrition and obesity, represents a growing concern in global health. This study examines the association of combined effects of obesity and malnutrition with the risk of stroke and brain structure.</p><p><strong>Methods: </strong>Data from the UK Biobank, a large-scale population-based cohort study, were analyzed. Patients were stratified into nourished nonobese, malnourished nonobese, nourished obese, and malnourished obese. Malnutrition risk using objective scores includes the Controlling Nutritional Status (CONUT) score, Nutritional Risk Index (NRI), and Prognostic Nutritional Index (PNI). Obesity was defined as BMI ≥30. Cox proportional hazard models were used to assess the association between combined obesity and nutritional status and incident stroke. Kaplan-Meier curves for incident stroke were constructed. Linear regression models were used to evaluate the associations between combined obesity and nutritional status and brain structure.</p><p><strong>Results: </strong>A total of 409,694 participants were included in the analysis. Among them, 37,930 participants had imaging data. Kaplan-Meier curves illustrated a higher incidence of stroke in the malnourished obese group. Malnourished obese was found to increase the risk of stroke (HRCONUT 1.27, 95% CI 1.09-1.48; HRNRI 2.61, 95% CI 2.03-3.36; HRPNI 7.9, 95%CI 1.11-56.07), ischemic stroke (HRCONUT 1.29, 95% CI 1.08-1.54; HRNRI 2.8, 95% CI 2.09-3.76; HRPNI 8.43, 95% CI 1.19-59.83), and hemorrhagic stroke (HRNRI 2.53, 95% CI 1.57-4.09). Brain imaging analysis revealed associations between malnourished obese and certain structural parameters. Cerebral white matter hyperintensities may be associated with the occurrence of stroke.</p><p><strong>Conclusion: </strong>Malnourished obese is associated with the risk of stroke and brain structure parameters. Further research is needed to better understand the underlying mechanisms and develop targeted interventions for individuals with combined effects of obesity and malnutrition.</p>","PeriodicalId":9683,"journal":{"name":"Cerebrovascular Diseases","volume":" ","pages":"1-9"},"PeriodicalIF":2.2000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coexisting Obesity and Malnutrition and its Impact on Stroke and Brain Structure: Insights from UK Biobank Study.\",\"authors\":\"Yajun Li, Pan Zhang, Yingjie Xu, Jinghui Zhong, Miaomiao Hu, Wen Sun, BuChun Zhang\",\"doi\":\"10.1159/000543819\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The dual burden of malnutrition, characterized by the coexistence of malnutrition and obesity, represents a growing concern in global health. This study examines the association of combined effects of obesity and malnutrition with the risk of stroke and brain structure.</p><p><strong>Methods: </strong>Data from the UK Biobank, a large-scale population-based cohort study, were analyzed. Patients were stratified into nourished nonobese, malnourished nonobese, nourished obese, and malnourished obese. Malnutrition risk using objective scores includes the Controlling Nutritional Status (CONUT) score, Nutritional Risk Index (NRI), and Prognostic Nutritional Index (PNI). Obesity was defined as BMI ≥30. Cox proportional hazard models were used to assess the association between combined obesity and nutritional status and incident stroke. Kaplan-Meier curves for incident stroke were constructed. Linear regression models were used to evaluate the associations between combined obesity and nutritional status and brain structure.</p><p><strong>Results: </strong>A total of 409,694 participants were included in the analysis. Among them, 37,930 participants had imaging data. Kaplan-Meier curves illustrated a higher incidence of stroke in the malnourished obese group. Malnourished obese was found to increase the risk of stroke (HRCONUT 1.27, 95% CI 1.09-1.48; HRNRI 2.61, 95% CI 2.03-3.36; HRPNI 7.9, 95%CI 1.11-56.07), ischemic stroke (HRCONUT 1.29, 95% CI 1.08-1.54; HRNRI 2.8, 95% CI 2.09-3.76; HRPNI 8.43, 95% CI 1.19-59.83), and hemorrhagic stroke (HRNRI 2.53, 95% CI 1.57-4.09). Brain imaging analysis revealed associations between malnourished obese and certain structural parameters. Cerebral white matter hyperintensities may be associated with the occurrence of stroke.</p><p><strong>Conclusion: </strong>Malnourished obese is associated with the risk of stroke and brain structure parameters. Further research is needed to better understand the underlying mechanisms and develop targeted interventions for individuals with combined effects of obesity and malnutrition.</p>\",\"PeriodicalId\":9683,\"journal\":{\"name\":\"Cerebrovascular Diseases\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-02-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cerebrovascular Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000543819\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebrovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000543819","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Coexisting Obesity and Malnutrition and its Impact on Stroke and Brain Structure: Insights from UK Biobank Study.
Introduction: The dual burden of malnutrition, characterized by the coexistence of malnutrition and obesity, represents a growing concern in global health. This study examines the association of combined effects of obesity and malnutrition with the risk of stroke and brain structure.
Methods: Data from the UK Biobank, a large-scale population-based cohort study, were analyzed. Patients were stratified into nourished nonobese, malnourished nonobese, nourished obese, and malnourished obese. Malnutrition risk using objective scores includes the Controlling Nutritional Status (CONUT) score, Nutritional Risk Index (NRI), and Prognostic Nutritional Index (PNI). Obesity was defined as BMI ≥30. Cox proportional hazard models were used to assess the association between combined obesity and nutritional status and incident stroke. Kaplan-Meier curves for incident stroke were constructed. Linear regression models were used to evaluate the associations between combined obesity and nutritional status and brain structure.
Results: A total of 409,694 participants were included in the analysis. Among them, 37,930 participants had imaging data. Kaplan-Meier curves illustrated a higher incidence of stroke in the malnourished obese group. Malnourished obese was found to increase the risk of stroke (HRCONUT 1.27, 95% CI 1.09-1.48; HRNRI 2.61, 95% CI 2.03-3.36; HRPNI 7.9, 95%CI 1.11-56.07), ischemic stroke (HRCONUT 1.29, 95% CI 1.08-1.54; HRNRI 2.8, 95% CI 2.09-3.76; HRPNI 8.43, 95% CI 1.19-59.83), and hemorrhagic stroke (HRNRI 2.53, 95% CI 1.57-4.09). Brain imaging analysis revealed associations between malnourished obese and certain structural parameters. Cerebral white matter hyperintensities may be associated with the occurrence of stroke.
Conclusion: Malnourished obese is associated with the risk of stroke and brain structure parameters. Further research is needed to better understand the underlying mechanisms and develop targeted interventions for individuals with combined effects of obesity and malnutrition.
期刊介绍：
A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
