PVP-I催化α-（三氟甲基）-苯乙烯与硫醇的羟基硫化：获得三氟甲基叔醇

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-02-06 DOI:10.1002/slct.202405351

Qian-Ding Zeng, Xinxin Yuan, Jian Wang, Hongmiao Yao, Bu-Bing Zeng, Jiangmeng Ren, Wu-Lin Yang

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引用次数: 0

摘要

以聚维酮-碘（PVP-I）为可循环催化剂，以空气为氧化剂，研究了一种高效合成β-羟基-β- cf3 -硫醚的方法。该反应在室温下顺利进行，以中等到较高的产率制得所需的β-羟基-β- cf3 -硫醚。这种方法可以放大到克级而不损失任何反应效率。催化剂可重复使用8次。研究了反应机理，提出了合理的反应途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

PVP-I Catalyzed Hydroxysulfurization of α-(Trifluoromethyl)-Styrenes with Thiols: Access to Trifluoromethyl Tertiary Alcohol

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PVP-I Catalyzed Hydroxysulfurization of α-(Trifluoromethyl)-Styrenes with Thiols: Access to Trifluoromethyl Tertiary Alcohol

An efficient method for the synthesis of β-hydroxy-β-CF₃-thioether has been developed, utilizing povidone-iodine (PVP-I) as a recyclable catalyst and air as the oxidant. The reaction proceeded smoothly at room temperature, yielding the desired β-hydroxy-β-CF₃-thioether in moderate to good yields. This method can be scaled up to gram-scale without losing any reaction efficiency. The catalyst was also recyclable up to 8 repetitions. The reaction mechanism was investigated and plausible reaction pathway was proposed.

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.