纳米等离子体生物传感中各向异性纳米粒子结构的形成

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-02-08 DOI:10.1007/s00604-025-06998-1

Chaoshan Zhao, Minshan Gan, Zhuoya Jiang, Zilan Lv, Wei Feng, Li Wang, Shunbo Li

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引用次数: 0

摘要

设计了一种由单金纳米棒和纳米球组成的各向异性纳米粒子结构。研究了其光学特性，特别是偏振光下的散射特性。信号读出是在微流控芯片中使用暗场微成像技术进行的。这种新结构的形成是由中间生物分子诱导的。因此，它在生物标志物的超灵敏检测中具有潜在的应用前景。以血管内皮生长因子（VEGF165）的检测为例，探讨了其特异性。这种独特的方法不仅有效地减少了背景干扰，而且为精确检测靶向肿瘤标志物提供了新的途径。图形抽象

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Formation of anisotropic nanoparticle structure for nanoplasmonic biosensing

A novel anisotropic nanoparticle structure consisting of a single gold nanorod and nanospheres is designed. The optical properties, especially the scattering under polarized light, are studied. The signal readout is conducted using dark-field microimaging techniques in a microfluidic chip. The formation of this novel structure is induced by the intermediate biomolecules. Therefore, it demonstrates potential applications in the ultrasensitive detection of biomarkers. As an example, the detection of vascular endothelial growth factor (VEGF165) is demonstrated, and the specificity is also investigated. This unique approach not only effectively reduces background interference but also provides a new approach for accurate sensing of targeted tumor markers.

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.