特发性CD4淋巴细胞减少症：肺囊虫性肺炎的罕见但致命的原因

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI:10.1016/j.rmcr.2025.102177

Julia Schearer , Christopher Merrick

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引用次数: 0

摘要

肺囊虫肺炎（PCP）是一种真菌感染，主要发生在免疫功能低下的个体由病原体肺囊虫。对于那些以前没有确定危险因素的患者，保持这种诊断的怀疑指数并寻找潜在的免疫抑制原因是至关重要的。在这里，我们报告了一个致命的PCP病例，患者没有已知的免疫功能低下史，随后被诊断为特发性CD4淋巴细胞减少症（ICL）， CD4+ t细胞绝对计数为7个细胞/uL。

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Idiopathic CD4 lymphocytopenia: An uncommon but fatal cause of Pneumocystis pneumonia

Pneumocystis pneumonia (PCP) is a fungal infection with primary occurrence in immunocompromised individuals by the etiologic agent Pneumocystis jirovecii. In those without previously identified risk factors, maintaining an index of suspicion for this diagnosis with search for underlying immunosuppressive cause is of utmost importance. Here, we present a case of fatal PCP in a patient without a known history of immunocompromise subsequently diagnosed with idiopathic CD4 lymphocytopenia (ICL) with an absolute CD4⁺ T-cell count of 7 cells/uL.

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