头颈癌患者同步高剂量顺铂放化疗后的感音神经性听力损失：营养和微量元素的作用

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY

Auris Nasus Larynx Pub Date : 2025-02-05 DOI:10.1016/j.anl.2025.01.013

Akira Ohkoshi , Ryo Ishii , Kenjiro Higashi , Satoshi Toyoma , Tadahisa Shishido , Takaya Yamamoto , Hinako Harada , Ayako Nakanome , Yukio Katori

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引用次数: 0

摘要

目的：听音神经性听力损失（SNHL）是高剂量顺铂同步放化疗治疗局部晚期头颈部鳞状细胞癌（HNSCC）的主要不良事件之一。本研究旨在探讨营养状况和微量元素对SNHL发病的影响。方法对109例接受高剂量顺铂CCRT治疗的HNSCC患者211耳进行回顾性分析。根据不良事件通用术语标准（CTCAE） 5.0版对各耳SNHL进行分类，并通过单因素和多因素分析评估可能的影响因素。以年龄、性别、原发部位、临床分期、治疗意向、吸烟和饮酒习惯、高血压史、糖尿病史、体重指数、血清白蛋白、微量元素（Fe、Zn、Cu、Se）、预处理2-8 kHz平均听力水平、体重减轻率、顺铂累积剂量、内耳辐射剂量为评价变量。结果随机logistic回归分析显示，年龄的增加、较好的预处理2-8 kHz平均听力水平和累积顺铂剂量是SNHL发生的独立因素。结论营养状况和微量元素与高剂量顺铂CCRT所致SNHL的发生无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Sensorineural hearing loss after concurrent chemoradiotherapy with high-dose cisplatin in head and neck cancer patients: Roles of nutrition and trace elements

Objective

Sensorineural hearing loss (SNHL) is one of the most important adverse events of concurrent chemoradiotherapy (CCRT) with high-dose cisplatin for locally advanced head and neck squamous cell carcinoma (HNSCC). This retrospective study aimed to elucidate the effects of nutritional status and trace elements on the development of SNHL.

Methods

A retrospective review of 211 ears from 109 patients with HNSCC who underwent CCRT with high-dose cisplatin was performed. SNHL of each ear was classified according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0, and possible contributing factors were evaluated by univariate and multivariate analyses. Age, sex, primary site, clinical stage, treatment intent, smoking and drinking habits, history of hypertension, diabetes mellitus, body mass index, serum albumin, trace elements (Fe, Zn, Cu, Se), pretreatment average hearing level at 2–8 kHz, weight loss rate, cumulative cisplatin dose, and inner ear radiation dose were the variables evaluated.

Results

Ordinal logistic regression analysis showed that increased age, better pretreatment average hearing level at 2–8 kHz, and cumulative cisplatin dose were independent factors associated with the development of SNHL.

Conclusion

Nutritional status and trace elements were not associated with the development of SNHL caused by CCRT with high-dose cisplatin.

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.