pd催化富电子杂芳烃的CH（苯磺酰基）二氟甲基化

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-02-05 DOI:10.1016/j.tetlet.2025.155486

Zi-En Liu , Tao Lin , Yue Zhao, Jun Cao

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引用次数: 0

摘要

研究了一种新的Pd(0)催化富电子杂芳烃的苯磺酰二氟甲基化反应。利用PhSO2CF2I作为（苯基磺酰基）二氟甲基化试剂的反应进行得很有效。机理研究表明，CH（苯磺酰基）二氟甲基化是通过自由基途径发生的。该方法具有广泛的底物相容性，包括各种含氮、氧和硫原子的杂环，获得了优异的产率。本研究为合成（苯基磺酰基）二氟甲基化杂环提供了一种高效、通用的方法，在医药、农用化学品和材料等领域具有重要价值。该方法反应条件温和，效率高，是扩大有机氟化学应用范围的一种很有前途的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pd-catalyzed CH (phenylsulfonyl)difluoromethylation of electron-rich heteroarenes

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Pd-catalyzed CH (phenylsulfonyl)difluoromethylation of electron-rich heteroarenes

A novel Pd(0)-catalyzed CH (phenylsulfonyl)difluoromethylation of electron-rich heteroarenes has been developed. The reaction utilizing PhSO₂CF₂I as a (phenylsulfonyl)difluoromethylation reagent proceeds efficiently. Mechanistic studies indicate that the CH (phenylsulfonyl)difluoromethylation occurs via a radical pathway. This method demonstrates broad substrate compatibility, including a variety of heterocycles containing nitrogen, oxygen, and sulfur atoms, achieving excellent yields. This study provides an efficient and versatile approach for synthesizing (phenylsulfonyl)difluoromethylated heterocycles, which are valuable in pharmaceuticals, agrochemicals, and materials. The mild reaction conditions and high efficiency of this method make it a promising tool for expanding the scope of organofluorine chemistry applications.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.