超越第一天的生物标志物:心肌肌钙蛋白I峰值在败血症预后中的关键作用

IF 2.6 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Dandan Zhao , Huimin Li , Yongdi Lin , Lizhen Liu , Lina Xu , Dan Zhang , Yu Fu , Jiang Hong , Congliang Miao
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引用次数: 0

摘要

脓毒症是一个具有高死亡率的全球性健康挑战。这需要及时识别风险和基于生物标志物的策略来优化ICU管理和结果。目的探讨心肌肌钙蛋白I (cTnI)和b型利钠肽(BNP)对脓毒症患者28天死亡率的预测价值。方法分析上海总医院重症监护病房脓毒症患者的临床资料。我们使用Cox模型和ROC曲线来评估cTnI和BNP水平与28天死亡率之间的关系及其预后准确性。结果本研究共纳入脓毒症患者333例,平均年龄[SD] 64.7[15.2]岁;65.8%为男性),其中63例(18.9%)患者在28天内死亡。在233例(70.0%)患者中发现cTnI峰值水平升高与脓毒症患者较高的28天死亡率独立相关,即使在调整SOFA评分、BNP和其他混杂变量后也是如此。(调整后的HR 2.33, 95% CI 1.08-5.04, P = 0.03)。然而,第一天的cTnI和BNP水平都不是28天死亡率的独立预测因子。对cTnI升高幅度作为预测变量的敏感性分析也得出了类似的结果。与第一天的cTnI、第一天的BNP和BNP峰值相比,cTnI峰值在ROC曲线下的面积最显著,也最适中(AUC: 0.64[0.57-0.71])。结论cTnI峰值升高或cTnI的大小,而不是第一天,可以独立预测脓毒症患者28天死亡的风险。这一发现强调了动态监测cTnI水平对脓毒症患者风险分层识别和管理的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beyond first-day biomarkers: The critical role of peak cardiac troponin I in sepsis prognosis

Background

Sepsis is a global health challenge with high mortality rates. It demands timely risk identification and biomarker-based strategies to optimize ICU management and outcomes.

Objectives

To explore the prognostic value of cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP) in predicting 28-day mortality in septic patients.

Methods

We analyzed clinical data of septic ICU patients at Shanghai General Hospital. We used Cox models and ROC curves to assess the association between cTnI and BNP levels and 28-day mortality, and their prognostic accuracy.

Results

A total of 333 septic patients were included in this study (mean age [SD], 64.7 [15.2] years; 65.8 % male), of whom 63 (18.9 %) patients died during 28 days. Elevated peak cTnI levels, identified in 233 patients (70.0 %), were independently associated with higher 28-day mortality in septic patients, even after adjusting for SOFA scores, BNP, and other confounding variables. (adjusted HR 2.33, 95 % CI 1.08–5.04, P = 0.03). However, neither first-day cTnI nor BNP levels remained independent predictors of 28-day mortality. Sensitivity analyses for the magnitude of cTnI elevation as a predictive variable also yielded similar results. Compared to first-day cTnI, first-day BNP, and peak BNP, the peak cTnI had the most significant and modest area under the ROC curve (AUC: 0.64 [0.57–0.71]).

Conclusion

Elevated peak cTnI or the magnitude of cTnI, rather than first-day, could independently predict the risk of 28-day mortality in septic patients. This finding highlighted the importance of dynamic monitoring cTnI levels for risk stratification identification and management in septic patients.
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来源期刊
Heart & Lung
Heart & Lung 医学-呼吸系统
CiteScore
4.60
自引率
3.60%
发文量
184
审稿时长
35 days
期刊介绍: Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.
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