Vitamins strategies for psoriasis: An update on current scientific evidence

Psoriasis is an aggressive chronic skin disorder that requires various therapies such as topical, oral, and occasionally, subcutaneous, or intravenous. In contrast, vitamins have more significant evidence in alteration to first-line therapies in the treatment of psoriasis. Vitamins such as fat-soluble and water-soluble supplements act as a secondary treatment that is given to reduce possible adverse effects from systematic medication, increase patient compliance, and consider affordable treatment costs. Here, the comparative study was conducted based on the data search from Pub Med, Google Scholar, Willy Library, etc., for both fat and water-soluble vitamins in psoriasis treatment first time. The present review summarizes the role of fat-soluble vitamins (A, D, E) and water-soluble vitamins (B₂, B₆, B₁₂, and C) based therapies in psoriasis treatment and result highlights the efficiency of oral supplementation of vitamins in psoriasis and systematic inflammation. Further, clinical studies along with in-vitro and in vivo based investigations have been compiled in this review, which shows that vitamins effectively can manage psoriasis. Additionally, the present review consists of chemical identification of both fat and water-soluble vitamins by High Performance Liquid Chromatography. The role of vitamins therapies in psoriasis management is promising and can be further to give in new horizon for improving the treatment efficacy. This review could provide an insight into vitamins emerging therapy in the treatments of psoriasis.