激光网格织构和硅油热处理改性钛颌骨药物储存器的液滴捕获机制和药物可持续释放

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-02-04 DOI:10.1016/j.colsurfb.2025.114552

Zhiwen Xiang , Maoyong Liu , Shufan Liu , Chengfeng Sun , Ping Nie , Chengdong Wang

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引用次数: 0

摘要

定制钛种植体通常用于修复因意外事故造成的下颌缺损。然而，口腔环境的半开放性质增加了种植体周围炎症的可能性，这对治疗结果有重大影响。大多数现有的研究都是通过表面修饰来实现药物装载，从而创建局部药物输送系统来解决这个问题。然而，在构建基于植入体结构的有效局部给药系统方面仍存在一些技术挑战。本研究采用激光网格变形和硅油热处理相结合的方法，设计并制作了钛药物储罐。分析了液滴捕获机理，评价了持续释放面积对液滴运动阻力的影响。体外抗菌实验表明，该修饰药物库具有高黏附和超疏水性的特点，具有较好的缓释效果。其织构间隔为500 µm，抑制区持续时间为60 h。该方法提出了一种制造钛植入物与局部给药系统集成的新方法，为改善临床结果提供了巨大的潜力。

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Droplet capture mechanism and sustainable drug release of a titanium mandibular drug reservoir modified by laser grid texturing and silicone oil heat treatment

Customized titanium implants are commonly used for repairing mandibular defects caused by accidents. However, the semi-open nature of the oral environment increases the likelihood of inflammation around the implant, which has a significant impact on the therapeutic outcomes. Most existing research tackles this issue by achieving drug loading through surface modifications to create local drug delivery systems. Nevertheless, several technical challenges remain in constructing effective local drug delivery systems based on the implant structure. In this study, a titanium drug reservoir was designed and fabricated, incorporating laser grid texturing and silicone oil heat treatment. The droplet capture mechanism was analyzed, and the effect of the sustainable release area on droplet motion resistance was evaluated. In vitro antibacterial tests revealed that the modified drug reservoir, characterized by high adhesion and superhydrophobicity, exhibited the most effective sustained release. It had a texturing interval of 500 µm, and the duration of the zone of inhibition was 60 h. This approach presents a new method for fabricating titanium implants integrated with local drug delivery systems, offering significant potential for improved clinical outcomes.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.