所有状态的脂肪组织：最新进展

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme Pub Date : 2023-12-01 DOI:10.1016/S0985-0562(24)00005-0

Elisa Doukbi , Adèle Lasbleiz , Anne Dutour , Bénédicte Gaborit

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引用次数: 0

摘要

肥胖是当今日益严重的全球健康问题。了解脂肪组织形成、生长和功能的机制对于对抗这种疾病及其相关并发症（如2型糖尿病和心血管疾病）至关重要。在法国，肥胖呈上升趋势，尤其是在年轻人和儿童中。在这篇综述中，我们讨论了白色脂肪组织的细胞组成，重点介绍了各种细胞群表征的最新进展。我们还探讨了身体脂肪分布的代谢意义，强调棕色和米色脂肪组织在代谢调节中的重要性。这些产热组织提供了显著的代谢益处，为研究和开发治疗肥胖相关代谢紊乱的治疗策略开辟了有希望的机会。此外，我们还讨论了细胞衰老与肥胖相关的代谢功能障碍之间的关系，以及细胞间通讯和线粒体循环领域的新研究。最后，本文综述了在脂肪细胞水平上对肥胖的理解的最新进展。©2023法国社会组织（SFNCM）。Elsevier Masson SAS出版。版权所有。

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Le tissu adipeux dans tous ses états : dernières avancées

Obesity represents a growing global health issue today. Understanding the mechanisms underlying the formation, growth, and function of adipose tissue is crucial in combating this disease and its associated complications, such as type 2 diabetes and cardiovascular diseases. In France, obesity is on the rise, particularly among young adults and children. In this review, we discuss the cellular composition of white adipose tissue, highlighting recent advances in the characterisation of various cell populations. We also explore the metabolic implications of body fat distribution, emphasizing the importance of brown and beige adipose tissues in metabolism regulation. These thermogenic tissues offer significant metabolic benefits, opening up promising opportunities in research and development of therapeutic strategies to address obesity-related metabolic disorders. Furthermore, we discuss the relationship between cellular senescence and obesity-related metabolic dysfunction, along with new research in the field of intercellular communication and mitochondrial recycling. Finally, this review provides a comprehensive overview of recent developments in the understanding of obesity at adipose cells level.

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来源期刊

Nutrition Clinique et Metabolisme 医学-内分泌学与代谢

CiteScore

0.80

自引率

16.70%

发文量

216

审稿时长

78 days

期刊介绍： Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.