解尿杆菌毒素对人和牛输卵管粘膜上皮的影响。

E A Fontaine, J B Clark, D Abeck, D Taylor-Robinson
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引用次数: 0

摘要

从非淋球菌性尿道炎患者尿道中分离到的9株解尿拟杆菌的无细菌滤液破坏了人输卵管和牛输卵管器官培养物的粘膜上皮。三天后出现的损伤表现为睫状体活动丧失。在扫描电镜的支持下,组织学观察显示,这种损失是由于上皮细胞脱落造成的。滤液的抑制活性可能是由于内毒素,因为从细菌中提取的脂多糖对输卵管粘膜上皮具有类似的有害作用。推测溶脲芽胞杆菌也可能通过相同的机制对尿道粘膜造成损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of a toxin from Bacteroides ureolyticus on the mucosal epithelium of human and bovine oviducts.

Bacteria-free filtrates of nine strains of Bacteroides ureolyticus, most of which had been isolated from the urethra of men with non-gonococcal urethritis, damaged the mucosal epithelium of human fallopian tube and bovine oviduct organ cultures. The damage, pronounced after three days, was manifested by loss of ciliary activity. Histological observations, supported by scanning electron microscopy, showed that this loss was due to disruption of the epithelia with sloughing of cells. It is likely that the inhibitory activity of the filtrates was due to endotoxin since lipopolysaccharides extracted from the bacteria had a similar deleterious effect on oviduct mucosal epithelia. It is speculated that B. ureolyticus has the potential for causing damage to the urethral mucosa by the same mechanism.

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