E A Fontaine, J B Clark, D Abeck, D Taylor-Robinson
{"title":"解尿杆菌毒素对人和牛输卵管粘膜上皮的影响。","authors":"E A Fontaine, J B Clark, D Abeck, D Taylor-Robinson","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Bacteria-free filtrates of nine strains of Bacteroides ureolyticus, most of which had been isolated from the urethra of men with non-gonococcal urethritis, damaged the mucosal epithelium of human fallopian tube and bovine oviduct organ cultures. The damage, pronounced after three days, was manifested by loss of ciliary activity. Histological observations, supported by scanning electron microscopy, showed that this loss was due to disruption of the epithelia with sloughing of cells. It is likely that the inhibitory activity of the filtrates was due to endotoxin since lipopolysaccharides extracted from the bacteria had a similar deleterious effect on oviduct mucosal epithelia. It is speculated that B. ureolyticus has the potential for causing damage to the urethral mucosa by the same mechanism.</p>","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"69 5","pages":"631-8"},"PeriodicalIF":0.0000,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013268/pdf/brjexppathol00005-0030.pdf","citationCount":"0","resultStr":"{\"title\":\"The effect of a toxin from Bacteroides ureolyticus on the mucosal epithelium of human and bovine oviducts.\",\"authors\":\"E A Fontaine, J B Clark, D Abeck, D Taylor-Robinson\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bacteria-free filtrates of nine strains of Bacteroides ureolyticus, most of which had been isolated from the urethra of men with non-gonococcal urethritis, damaged the mucosal epithelium of human fallopian tube and bovine oviduct organ cultures. The damage, pronounced after three days, was manifested by loss of ciliary activity. Histological observations, supported by scanning electron microscopy, showed that this loss was due to disruption of the epithelia with sloughing of cells. It is likely that the inhibitory activity of the filtrates was due to endotoxin since lipopolysaccharides extracted from the bacteria had a similar deleterious effect on oviduct mucosal epithelia. It is speculated that B. ureolyticus has the potential for causing damage to the urethral mucosa by the same mechanism.</p>\",\"PeriodicalId\":9248,\"journal\":{\"name\":\"British journal of experimental pathology\",\"volume\":\"69 5\",\"pages\":\"631-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013268/pdf/brjexppathol00005-0030.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British journal of experimental pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of experimental pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of a toxin from Bacteroides ureolyticus on the mucosal epithelium of human and bovine oviducts.
Bacteria-free filtrates of nine strains of Bacteroides ureolyticus, most of which had been isolated from the urethra of men with non-gonococcal urethritis, damaged the mucosal epithelium of human fallopian tube and bovine oviduct organ cultures. The damage, pronounced after three days, was manifested by loss of ciliary activity. Histological observations, supported by scanning electron microscopy, showed that this loss was due to disruption of the epithelia with sloughing of cells. It is likely that the inhibitory activity of the filtrates was due to endotoxin since lipopolysaccharides extracted from the bacteria had a similar deleterious effect on oviduct mucosal epithelia. It is speculated that B. ureolyticus has the potential for causing damage to the urethral mucosa by the same mechanism.