Xin Zhao, Guixin Yang*, Mengmeng Huang, Rui Zhang, Hongtao Liu, Yuhang Wang, Zhe Yan and Piaoping Yang*,
{"title":"NIR-II光引发cu2se基热响应多功能纳米材料用于癌症治疗","authors":"Xin Zhao, Guixin Yang*, Mengmeng Huang, Rui Zhang, Hongtao Liu, Yuhang Wang, Zhe Yan and Piaoping Yang*, ","doi":"10.1021/acsanm.4c0613110.1021/acsanm.4c06131","DOIUrl":null,"url":null,"abstract":"<p >There is an urgent need to explore photothermal conversion agents and more effective treatment methods that are sensitive to the second near-infrared window. Based on this, we designed a more comprehensive treatment system combining photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy ingeniously, which is quite innovative and promising for treating tumors, especially in hypoxic environments. The Cu<sub>2</sub>Se-based nanoplatform was constructed and controlled by the coating of a mesoporous SiO<sub>2</sub> shell, and the large mesoporous structure was then filled with DOX which exhibits dual responses to changes in pH and NIR-II. When irradiated by a 1064 nm laser, the photothermal agent of Cu<sub>2</sub>Se plays an important role in initiating the switch in the whole nanoplatform whose hyperthermia not only realized fundamental PTT but also converted H<sub>2</sub>O<sub>2</sub> into biotoxic reactive oxygen species (ROS) such as ·OH, ·O<sub>2</sub><sup>–</sup> through intracellular Cu<sup>+</sup>/Cu<sup>2+</sup> circulating response. Besides, the encapsulation of the drug doxorubicin (DOX) in mesoporous SiO<sub>2</sub> prevents early drug leakage. High permeability and retention of the tumor site allow nanoparticles to accumulate and be engulfed by cells, and DOX will be rapidly released due to a decrease in pH in the tumor environment. As expected, cell experiment in vitro and mice experiment in vivo further assessed the excellent biocompatibility and antitumor effects, indicating that the nanoplatform of Cu<sub>2</sub>Se@mSiO<sub>2</sub>-PEG-DOX showed promise for simultaneous treatment in hypoxic cancer therapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 5","pages":"2216–2227 2216–2227"},"PeriodicalIF":5.5000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cu2Se-Based Thermoresponsive Multifunctional Nanomaterial Initiated by NIR-II Light for Cancer Therapy\",\"authors\":\"Xin Zhao, Guixin Yang*, Mengmeng Huang, Rui Zhang, Hongtao Liu, Yuhang Wang, Zhe Yan and Piaoping Yang*, \",\"doi\":\"10.1021/acsanm.4c0613110.1021/acsanm.4c06131\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >There is an urgent need to explore photothermal conversion agents and more effective treatment methods that are sensitive to the second near-infrared window. Based on this, we designed a more comprehensive treatment system combining photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy ingeniously, which is quite innovative and promising for treating tumors, especially in hypoxic environments. The Cu<sub>2</sub>Se-based nanoplatform was constructed and controlled by the coating of a mesoporous SiO<sub>2</sub> shell, and the large mesoporous structure was then filled with DOX which exhibits dual responses to changes in pH and NIR-II. When irradiated by a 1064 nm laser, the photothermal agent of Cu<sub>2</sub>Se plays an important role in initiating the switch in the whole nanoplatform whose hyperthermia not only realized fundamental PTT but also converted H<sub>2</sub>O<sub>2</sub> into biotoxic reactive oxygen species (ROS) such as ·OH, ·O<sub>2</sub><sup>–</sup> through intracellular Cu<sup>+</sup>/Cu<sup>2+</sup> circulating response. Besides, the encapsulation of the drug doxorubicin (DOX) in mesoporous SiO<sub>2</sub> prevents early drug leakage. High permeability and retention of the tumor site allow nanoparticles to accumulate and be engulfed by cells, and DOX will be rapidly released due to a decrease in pH in the tumor environment. As expected, cell experiment in vitro and mice experiment in vivo further assessed the excellent biocompatibility and antitumor effects, indicating that the nanoplatform of Cu<sub>2</sub>Se@mSiO<sub>2</sub>-PEG-DOX showed promise for simultaneous treatment in hypoxic cancer therapy.</p>\",\"PeriodicalId\":6,\"journal\":{\"name\":\"ACS Applied Nano Materials\",\"volume\":\"8 5\",\"pages\":\"2216–2227 2216–2227\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Nano Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsanm.4c06131\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.4c06131","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Cu2Se-Based Thermoresponsive Multifunctional Nanomaterial Initiated by NIR-II Light for Cancer Therapy
There is an urgent need to explore photothermal conversion agents and more effective treatment methods that are sensitive to the second near-infrared window. Based on this, we designed a more comprehensive treatment system combining photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy ingeniously, which is quite innovative and promising for treating tumors, especially in hypoxic environments. The Cu2Se-based nanoplatform was constructed and controlled by the coating of a mesoporous SiO2 shell, and the large mesoporous structure was then filled with DOX which exhibits dual responses to changes in pH and NIR-II. When irradiated by a 1064 nm laser, the photothermal agent of Cu2Se plays an important role in initiating the switch in the whole nanoplatform whose hyperthermia not only realized fundamental PTT but also converted H2O2 into biotoxic reactive oxygen species (ROS) such as ·OH, ·O2– through intracellular Cu+/Cu2+ circulating response. Besides, the encapsulation of the drug doxorubicin (DOX) in mesoporous SiO2 prevents early drug leakage. High permeability and retention of the tumor site allow nanoparticles to accumulate and be engulfed by cells, and DOX will be rapidly released due to a decrease in pH in the tumor environment. As expected, cell experiment in vitro and mice experiment in vivo further assessed the excellent biocompatibility and antitumor effects, indicating that the nanoplatform of Cu2Se@mSiO2-PEG-DOX showed promise for simultaneous treatment in hypoxic cancer therapy.
期刊介绍:
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.