NIR-II光引发cu2se基热响应多功能纳米材料用于癌症治疗

IF 5.5 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Xin Zhao, Guixin Yang*, Mengmeng Huang, Rui Zhang, Hongtao Liu, Yuhang Wang, Zhe Yan and Piaoping Yang*, 
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引用次数: 0

摘要

迫切需要探索对第二近红外窗口敏感的光热转换剂和更有效的处理方法。在此基础上,我们巧妙地设计了光热疗法(PTT)、光动力疗法(PDT)和化疗相结合的更全面的治疗系统,对于治疗肿瘤,特别是在缺氧环境下的肿瘤,具有相当的创新性和前景。在cu2se基纳米平台上涂覆一层介孔SiO2外壳,然后在大介孔结构中填充DOX, DOX对pH和NIR-II的变化具有双重响应。在1064 nm激光照射下,光热剂Cu2Se在启动整个纳米平台的开关中起着重要作用,其热疗不仅实现了基本的PTT,而且通过细胞内Cu+/Cu2+循环反应将H2O2转化为生物毒性活性氧(ROS),如·OH,·O2 -。此外,药物多柔比星(DOX)被包封在介孔SiO2中可以防止药物早期泄漏。肿瘤部位的高渗透性和滞留性允许纳米颗粒积聚并被细胞吞噬,并且由于肿瘤环境pH值的降低,DOX将迅速释放。正如预期的那样,体外细胞实验和小鼠体内实验进一步评估了优异的生物相容性和抗肿瘤作用,表明Cu2Se@mSiO2-PEG-DOX纳米平台在低氧癌症治疗中具有同步治疗的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cu2Se-Based Thermoresponsive Multifunctional Nanomaterial Initiated by NIR-II Light for Cancer Therapy

Cu2Se-Based Thermoresponsive Multifunctional Nanomaterial Initiated by NIR-II Light for Cancer Therapy

There is an urgent need to explore photothermal conversion agents and more effective treatment methods that are sensitive to the second near-infrared window. Based on this, we designed a more comprehensive treatment system combining photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy ingeniously, which is quite innovative and promising for treating tumors, especially in hypoxic environments. The Cu2Se-based nanoplatform was constructed and controlled by the coating of a mesoporous SiO2 shell, and the large mesoporous structure was then filled with DOX which exhibits dual responses to changes in pH and NIR-II. When irradiated by a 1064 nm laser, the photothermal agent of Cu2Se plays an important role in initiating the switch in the whole nanoplatform whose hyperthermia not only realized fundamental PTT but also converted H2O2 into biotoxic reactive oxygen species (ROS) such as ·OH, ·O2 through intracellular Cu+/Cu2+ circulating response. Besides, the encapsulation of the drug doxorubicin (DOX) in mesoporous SiO2 prevents early drug leakage. High permeability and retention of the tumor site allow nanoparticles to accumulate and be engulfed by cells, and DOX will be rapidly released due to a decrease in pH in the tumor environment. As expected, cell experiment in vitro and mice experiment in vivo further assessed the excellent biocompatibility and antitumor effects, indicating that the nanoplatform of Cu2Se@mSiO2-PEG-DOX showed promise for simultaneous treatment in hypoxic cancer therapy.

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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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