接触和交流：ZO-2和河马通路。

The FEBS journal Pub Date : 2025-02-05 DOI:10.1111/febs.17417

Miranda Thomas

{"title":"接触和交流：ZO-2和河马通路。","authors":"Miranda Thomas","doi":"10.1111/febs.17417","DOIUrl":null,"url":null,"abstract":"The PDZ domain-containing protein ZO-2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the multiple protein binding sites of ZO2 protein allow it to act as a scaffold to facilitate its signalling functions.","PeriodicalId":94226,"journal":{"name":"The FEBS journal","volume":"292 7","pages":"1584-1586"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/febs.17417","citationCount":"0","resultStr":"{\"title\":\"Contact and communication: ZO-2 and the Hippo pathway\",\"authors\":\"Miranda Thomas\",\"doi\":\"10.1111/febs.17417\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The PDZ domain-containing protein ZO-2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the multiple protein binding sites of ZO2 protein allow it to act as a scaffold to facilitate its signalling functions.\",\"PeriodicalId\":94226,\"journal\":{\"name\":\"The FEBS journal\",\"volume\":\"292 7\",\"pages\":\"1584-1586\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/febs.17417\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The FEBS journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/febs.17417\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The FEBS journal","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/febs.17417","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

含 PDZ 结构域的蛋白 ZO-2 被定义为紧密连接（TJ）蛋白，但已知它还在维持细胞顶端极性方面发挥作用，并在包括 Hippo 通路在内的几条通路中发挥信号分子的功能。本期，Liu OX 等人[(2024) FEBS J, https://doi.org/10.1111/febs.17304]报告了 ZO2 蛋白的多个蛋白结合位点如何使其充当支架以促进其信号功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Contact and communication: ZO-2 and the Hippo pathway

查看原文本刊更多论文

Contact and communication: ZO-2 and the Hippo pathway

The PDZ domain-containing protein ZO-2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the multiple protein binding sites of ZO2 protein allow it to act as a scaffold to facilitate its signalling functions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The FEBS journal

自引率

0.00%

发文量