The FEBS journal

Rational design of Chim3, a multifunctional peptide carrying a formyl peptide receptor 2 (FPR2) agonist module released by bacterial signal peptidase I (Spase I).

Pub Date : 2025-03-12 DOI: 10.1111/febs.70055 Samuel R Costa, Bianca O Lira, Gabriel F G Calixto, João B Nunes, Sabrina A Machado, Andreanne G Vasconcelos, Ana L P Lourenço, Thaís C de Sousa, Sónia Gonçalves, André M Murad, Nuno C Santos, José R de S de Almeida Leite, Kelly G Magalhães, Marcelo S Ramada, Guilherme D Brand

A steric gate prevents mutagenic dATP incorporation opposite 8-oxo-deoxyguanosine in mitochondrial DNA polymerases.

Pub Date : 2025-03-12 DOI: 10.1111/febs.70064 Noe Baruch-Torres, Carlos H Trasviña-Arenas, Alexandru Ionut Gilea, Upeksha C Dissanayake, Missael Molina-Jiménez, Paola L García-Medel, Corina Díaz-Quezada, Tiziana Lodi, G Andrés Cisneros, Enrico Baruffini, Luis G Brieba

Caspase-1/11 controls Zika virus replication in astrocytes by inhibiting glycolytic metabolism.

Pub Date : 2025-03-12 DOI: 10.1111/febs.70061 Ingrid S de Farias, Guilherme Ribeiro, Isaú H Noronha, Victoria Weise L Lucena, Jean P S Peron, Pedro M Moraes-Vieira, Jose C Alves-Filho, Karina R Bortoluci