激光诱导最小化循环肿瘤细胞抑制肿瘤转移。

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Da Sun, Bingchen Yu, Rui Xu, Chenzheng Wang, Kai Pang
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引用次数: 0

摘要

循环肿瘤细胞(CTCs)是肿瘤转移的关键指标。有效清除ctc可降低转移的可能性。我们设计了一个实时动态监测和清除CTCs的系统,能够监测和清除生命循环系统中的CTCs。实验结果表明,脉冲激光治疗显著影响黑色素瘤ctc的清除。通过小动物体内成像和小鼠生存分析,我们发现CTC清除可以减小远处转移灶的大小,延长小鼠的寿命。此外,我们建立了一个溶血实验,以证明所使用的激光能量不会对红细胞造成损害。这项研究是基于ctc的物理和机械破坏,这意味着不存在耐药性问题。这为临床抑制肿瘤转移和延长患者寿命提供了新的途径和技术手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Laser-Induced Minimization of Circulating Tumor Cells to Suppress Tumor Metastasis

Circulating tumor cells (CTCs) are key indicators of tumor metastasis. Effective clearance of CTCs can reduce the probability of metastasis. We designed a system for the real-time dynamic monitoring and clearance of CTCs, capable of monitoring and clearing CTCs in the living circulatory system. Experimental results showed that pulsed laser treatment significantly affects the clearance of melanoma CTCs. Through in vivo imaging of small animals and survival analysis of mice, we observed that CTC clearance could reduce the size of distant metastatic lesions and prolong the lifespan of the mice. Additionally, we set up a hemolysis experiment to demonstrate that the laser energy used does not cause damage to red blood cells. This study is based on the physical and mechanical destruction of CTCs, meaning there is no issue of drug resistance. This provides a novel approach and technical means for suppressing tumor metastasis and extending the lifespan of patients in clinical settings.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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