儿童复发性眼睑皮肤黏液瘤伴基底细胞增生1例。

IF 1.1 4区 医学 Q4 DERMATOLOGY
American Journal of Dermatopathology Pub Date : 2025-06-01 Epub Date: 2025-02-06 DOI:10.1097/DAD.0000000000002926
Margaryta Stoieva, Emily O'Donnell
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引用次数: 0

摘要

摘要:皮肤黏液瘤在儿科人群中极为罕见。我们报告一个8岁儿童眼睑皮肤黏液瘤多发性复发的病例。病变曾经被诊断为内分泌汗腺瘤切除了三次,随后复发。在第四次切除时进行的冷冻切片诊断显示出明显的基底细胞样特征,促使最终诊断推迟到永久切片。常规处理后,除了黏液瘤的背景特征外,基底细胞增生没有明显的异型性或有丝分裂活性。CD10免疫染色显示基底样细胞巢和周围基质。确诊为皮肤黏液瘤。这一诊断得到了外部会诊的证实。患者接受了卡尼复合物的基因检测,结果为阴性。本案例报告提出了一些实用的观点。首先,由于其在儿科人群中的罕见性和潜在的模仿其他实体,皮肤黏液瘤可能被误诊为其他良性肿瘤。其次,尽管在黏液瘤中诱导基底细胞增殖已被充分证明,但它很容易被误解为恶性过程,特别是在冷冻切片诊断和缺乏可用临床信息的情况下。第三,尽管孤立性皮肤黏液瘤不太可能与卡尼复合体相关,但这种关联的可能性应始终牢记在心,因为缺失综合征性肿瘤(如心脏黏液瘤)的后果可能是致命的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case of Recurrent Eyelid Cutaneous Myxoma With Basaloid Proliferation in a Child.

Abstract: Cutaneous myxomas are extremely rare in the pediatric population. We describe a case of an eyelid cutaneous myxoma with multiple recurrences in an 8-year-old child. The lesion once previously diagnosed as eccrine hidrocystoma had been excised three times with subsequent recurrence. Frozen section diagnosis performed during the fourth excision showed striking basaloid features, prompting deferral of definitive diagnosis to permanent sections. Following routine processing, basaloid proliferations were again seen without significant atypia or mitotic activity in addition to background features of myxoma. CD10 immunostain highlighted both basaloid nests and surrounding stroma. Cutaneous myxoma was diagnosed. The diagnosis was corroborated by an external consultation. The patient underwent genetic testing for the Carney complex with negative results. This case report raises some practical points. First, due to their rarity in the pediatric population and potential to mimic other entities, cutaneous myxomas can be misdiagnosed as other benign neoplasms. Second, although induction of basaloid proliferation has been well-documented in myxoma, it can be easily misinterpreted as a malignant process, particularly in the setting of a frozen section diagnosis and lack of available clinical information. Third, even though solitary cutaneous myxomas are less likely to be associated with the Carney complex, a possibility of such an association should always be born in mind, as consequences of missing syndromic neoplasms, such as cardiac myxoma, can be lethal.

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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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