用于声动力治疗的声敏剂：目前进展和未来展望。

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-02-05 DOI:10.1016/j.ultrasmedbio.2025.01.011

Ting Wang , Meng Du , Zhiyi Chen

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引用次数: 0

摘要

声动力治疗（SDT）是一种结合低强度超声和声敏剂的新型无创治疗方法。与光动力治疗相比，SDT具有穿透组织深度深、准确性高、不良反应少等优点。超声增敏剂对SDT的疗效至关重要。超声增敏剂具有结构清晰、易于监测、评价药物代谢和临床转化等优点。值得注意的是，生物化学技术可用于声敏剂和SDT领域，以克服固有障碍，实现可持续创新。本文首先综述了SDT的分子机制，重点介绍了有机声敏剂、无机纳米声敏剂以及经过一系列修饰后具有靶向、穿透和成像功能的多功能给药系统。本文综述为超声增敏剂和SDT的设计提供思路和参考，促进其进一步向临床应用转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sonosensitizers for Sonodynamic Therapy: Current Progress and Future Perspectives

Sonodynamic therapy (SDT) is a novel non-invasive treatment method that combines low-intensity ultrasound and sonosensitizers. Compared with photodynamic therapy, SDT has the advantages of deeper tissue penetration, higher accuracy and fewer adverse reactions. Sonosensitizers are essential for the efficacy of SDT. Sonosensitizers have the advantages of clear structure, easy monitoring, evaluation of drug metabolism and clinical transformation, etc. Notably, biochemical techniques can be used in the field of sonosensitizers and SDT to overcome inherent barriers and achieve sustainable innovation. This article first summarizes the molecular mechanism of SDT, focusing on organic sonosensitizers, inorganic nano-sonosensitizers and multi-functional drug delivery systems with targeting, penetration and imaging functions after a series of modifications. This review provides ideas and references for the design of sonosensitizers and SDT and promotes their future transformation into clinical applications.

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.