在有或没有冠心病家族史的患者中,脂蛋白(a)水平与冠心病(CAD)的关系

Q2 Medicine
Journal of Lipid and Atherosclerosis Pub Date : 2025-01-01 Epub Date: 2024-12-26 DOI:10.12997/jla.2025.14.1.120
Hayato Tada, Nobuko Kojima, Kan Yamagami, Yasuaki Takeji, Kenji Sakata, Soichiro Usui, Masa-Aki Kawashiri, Masayuki Takamura
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引用次数: 0

摘要

目的:脂蛋白(a) (Lp[a])是一种高度遗传性状,与冠状动脉疾病(CAD)相关。然而,关于Lp(a)与CAD之间的关联是否因CAD家族史而异,目前尚不清楚。方法:我们调查了2008年至2016年在金泽大学医院接受血清Lp(a)水平测量的4512名参与者的临床资料。根据冠心病家族史,采用logistic回归分析Lp(a)与冠心病的关系。结果:CAD家族史和Lp(a)水平与CAD发展显著相关(优势比[OR], 1.32;95%置信区间[CI], 1.12-1.52;结论:与冠心病家族史无关,Lp(a)水平与冠心病发展相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Lipoprotein (a) Levels and Coronary Artery Disease (CAD) Among Patients With or Without CAD Family History.

Objective: Lipoprotein (a) (Lp[a]), which is a highly heritable trait, is associated with coronary artery disease (CAD). However, the insight into whether the association between Lp(a) and CAD differs according to the family history of CAD remains unclear.

Methods: We investigated clinical data of 4,512 participants who underwent serum Lp(a) level measurement at Kanazawa University Hospital between 2008 and 2016. The association between Lp(a) and CAD according to CAD family history was investigated through logistic regression analyses.

Results: CAD family history and Lp(a) levels were significantly associated with CAD development (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.12-1.52; p<0.001 and OR, 1.13; 95% CI, 1.03-1.23; p<0.001 per 10 mg/dL, respectively). In patients without CAD family history, those with Lp(a) levels ≥30 mg/dL had higher CAD risk than those with Lp(a) levels <30 mg/dL (reference) (OR, 1.33; 95% CI, 1.05-1.61; p<0.001). In patients with CAD family history, those who had Lp(a) levels <30 and ≥30 mg/dL were both highly at risk for CAD (OR, 1.24; 95% CI, 1.04-1.44; p<0.001 and OR, 1.68; 95% CI, 1.34-2.02; p<0.001, respectively). Adding CAD family history and Lp(a) information to other conventional risk factors enhanced CAD risk discrimination (C-statistics: 0.744 [0.704-0.784] to 0.768 [0.730-0.806], and 0.791 [0.751-0.831], respectively; p<0.05 for both).

Conclusion: Lp(a) level was associated with CAD development regardless of CAD family history status.

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来源期刊
Journal of Lipid and Atherosclerosis
Journal of Lipid and Atherosclerosis Medicine-Internal Medicine
CiteScore
6.90
自引率
0.00%
发文量
26
审稿时长
12 weeks
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