布洛芬阻止质粒介导的抗菌素耐药基因的共轭转移。

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

Journal of global antimicrobial resistance Pub Date : 2025-02-03 DOI:10.1016/j.jgar.2025.01.012

Guangfen Zhang , Chunli Li , Xiaofan Li , Yuanyuan Li , Yunbing Li , Xiangkun Zeng , Chen Xu , Shuyan Wu , Ning Dong

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引用次数: 0

摘要

耐多药细菌（MDRB）引起的难治性感染对公众健康构成重大威胁。我们报道了布洛芬抑制RP4质粒与携带不同耐药基因的临床菌株的质粒结合，这些基因包括mcr-1、blaNDM、blaKPC、tet（X4）和tmexCD1-toprJ1。机制研究表明，布洛芬减少ATP的产生并抑制偶联相关基因。布洛芬对结合的抑制作用对预防耐多药的传播具有重要的临床意义，为对抗耐多药耐药性开辟了新的治疗途径。

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Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes

Refractory infections caused by multidrug-resistant bacteria pose a significant threat to public health. Here we report that ibuprofen inhibits conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, bla_NDM, bla_KPC, tet(X4), and tmexCD1-toprJ1. Mechanistic studies suggest that ibuprofen reduces ATP production and inhibits conjugation-related genes. The inhibitory effect of ibuprofen on conjugation has significant clinical implications for preventing the spread of multidrug resistance, opening new therapeutic avenues to combat multidrug-resistant bacteria.

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来源期刊

Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

8.70

自引率

2.20%

发文量

285

审稿时长

34 weeks

期刊介绍： The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.