具有聚集诱导发射特性的无反应线粒体膜电位独立发光源用于活神经元成像。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-01-30 DOI:10.1039/D4CC06022A

Hojeong Park, Guangle Niu, Alex Y. H. Wong, Eric Y. Yu, Ryan T. K. Kwok and Ben Zhong Tang

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引用次数: 0

摘要

我们开发了一种新型的以氰基苯乙烯为核心的聚集诱导发射（AIE）发光源为基础的光稳定性线粒体靶向探针。在吡啶基团上引入烷基链增强了它们与线粒体膜的相互作用。这种设计有效地防止了线粒体膜去极化后探针泄漏，同时显著降低了细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging†

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Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging†

We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.