He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang
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A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice (4/2024)
In this article number 10.1002/bmm2.12104, He Ren, Zewen Wu, Liyun Zhang, Yumiao Zhang and their co-authors designed an antirheumatic nanoparticle termed CeViM-micelle@B. A methotrexate-conjugated Pluronic F127 micelle was developed to encapsulate anti-inflammatory agent Celastrol (Cel) and the stabilizer Vitamin K (VK), which was further coated by B-cell membrane. The use of CeViM-micelle@B significantly increased drug accumulation at pathological synovial joints, potently inhibited immune cell activation, and effectively prevented erosion of bone and cartilage. This new nanoplatform holds potential for the next-generation targeted rheumatoid arthritis therapy.
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