黑素和神经递质信号基因在白色和红色仓鸮生长羽毛中的差异共表达

IF 2.6 3区 医学 Q2 CELL BIOLOGY
Anne-Lyse Ducrest, Luis M. San-Jose, Samuel Neuenschwander, Emanuel Schmid-Siegert, Céline Simon, Marco Pagni, Christian Iseli, Hannes Richter, Nicolas Guex, Tristan Cumer, Emmanuel Beaudoing, Mélanie Dupasquier, Pauline Charruau, Pauline Ducouret, Ioannis Xenarios, Jérôme Goudet, Alexandre Roulin
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引用次数: 0

摘要

以黑色素为基础的色素沉着的调控是复杂的,涉及多个基因。因为不同的基因可以导致相同的色素沉着表型,在模式生物中鉴定的基因不一定适用于野生物种。在仓鸮(Tyto alba)中,腹侧羽毛的颜色从白色到红褐色不等,黑素皮质素1受体基因(MC1R)的遗传变异至少占这种变异的三分之一。在本研究中,我们利用转录组学数据比较了不同MC1R基因型雏鸟生长羽毛的基因表达谱。我们鉴定了21个差异表达基因,其中9个与黑色素形成有关,而7个与神经递质功能或突触活性有关。除了CALB1外,与白色仓鸮相比,所有差异表达基因在褐猫头鹰中都上调。据我们所知,这项研究是第一个将黑色素生成与神经递质相关基因联系起来的研究,我们讨论了这种联系的可能的进化解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls

Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls

Regulation of melanin-based pigmentation is complex, involving multiple genes. Because different genes can contribute to the same pigmentation phenotype, the genes identified in model organisms may not necessarily apply to wild species. In the barn owl (Tyto alba), ventral plumage colour ranges from white to rufous, with genetic variation in the melanocortin 1 receptor gene (MC1R) accounting for at least a third of this variation. In the present study, we used transcriptomic data to compare the gene expression profiles of growing feathers from nestlings with different MC1R genotypes. We identified 21 differentially expressed genes, nine of which are involved in melanogenesis, while seven are related to neurotransmitter function or synaptic activity. With the exception of CALB1, all of the differentially expressed genes were upregulated in rufous owls compared to white barn owls. To the best of our knowledge, this study is the first to link melanin production with neurotransmitter-related genes, and we discuss possible evolutionary explanations for this connection.

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来源期刊
Pigment Cell & Melanoma Research
Pigment Cell & Melanoma Research 医学-皮肤病学
CiteScore
8.90
自引率
2.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders
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