{"title":"帕金森病患者发病前和当前的智力表现反映了不同的背景","authors":"Hidetomo Murakami, Machiko Kezuka, Junnosuke Ozawa, Kaoru Matsuoka, Tatsuya Nakanishi, Atsushi Ishida, Naohito Ito, Mizuki Kanemoto, Mitsuru Kawamura","doi":"10.1016/j.ahr.2025.100221","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>There is growing interest in targeting Parkinson's Disease (PD) at an earlier stage, especially before emergence of motor symptoms. Cognitive dysfunction is a non-motor symptom in PD, whereas the Japanese version of the National Adult Reading Test (JART) is a validated battery to estimate the premorbid intellectual quotient (IQ). Therefore, the results of JART and current cognitive assessment after onset of PD may reflect different background factors. The goal of the study was to compare factors correlated with estimated premorbid intellectual performance using JART and current cognitive function after onset of PD.</div></div><div><h3>Methods</h3><div>Current motor symptoms (Unified Parkinson's Disease Rating Scale; UPDRS Part III) and cognitive function (Montreal Cognitive Assessment; MoCA) were assessed in 48 patients with PD. Premorbid IQs (verbal IQ: VIQ, performance IQ: PIQ, and full scale IQ: FIQ) were estimated using JART. Spearman correlation coefficients were calculated for background factors (current age, years of education, UPDRS Part III, and levodopa equivalent dose of prescribed drugs (LED)) with MoCA scores and estimated IQs.</div></div><div><h3>Results</h3><div>Estimated VIQ (<em>r</em> = 0.451, <em>p</em> = 0.001), PIQ (<em>r</em> = 0.445, <em>p</em> = 0.002) and FIQ (<em>r</em> = 0.453, <em>p</em> = 0.001) were significantly correlated with years of education that was fixed until adolescence (i.e. 20 s). MoCA was significantly correlated with current age (<em>r</em>=−0.401, <em>p</em> = 0.005) and UPDRS part III (<em>r</em>=−0.374, <em>p</em> = 0.009), both of which continue to progress gradually after onset of PD. In multiple regression analyses, these correlations were significant and independent.</div></div><div><h3>Conclusion</h3><div>Premorbid and current intellectual performance reflect different background factors in patients with PD.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100221"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Premorbid and current intellectual performance reflects different backgrounds in patients with Parkinson's disease\",\"authors\":\"Hidetomo Murakami, Machiko Kezuka, Junnosuke Ozawa, Kaoru Matsuoka, Tatsuya Nakanishi, Atsushi Ishida, Naohito Ito, Mizuki Kanemoto, Mitsuru Kawamura\",\"doi\":\"10.1016/j.ahr.2025.100221\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>There is growing interest in targeting Parkinson's Disease (PD) at an earlier stage, especially before emergence of motor symptoms. Cognitive dysfunction is a non-motor symptom in PD, whereas the Japanese version of the National Adult Reading Test (JART) is a validated battery to estimate the premorbid intellectual quotient (IQ). Therefore, the results of JART and current cognitive assessment after onset of PD may reflect different background factors. The goal of the study was to compare factors correlated with estimated premorbid intellectual performance using JART and current cognitive function after onset of PD.</div></div><div><h3>Methods</h3><div>Current motor symptoms (Unified Parkinson's Disease Rating Scale; UPDRS Part III) and cognitive function (Montreal Cognitive Assessment; MoCA) were assessed in 48 patients with PD. Premorbid IQs (verbal IQ: VIQ, performance IQ: PIQ, and full scale IQ: FIQ) were estimated using JART. Spearman correlation coefficients were calculated for background factors (current age, years of education, UPDRS Part III, and levodopa equivalent dose of prescribed drugs (LED)) with MoCA scores and estimated IQs.</div></div><div><h3>Results</h3><div>Estimated VIQ (<em>r</em> = 0.451, <em>p</em> = 0.001), PIQ (<em>r</em> = 0.445, <em>p</em> = 0.002) and FIQ (<em>r</em> = 0.453, <em>p</em> = 0.001) were significantly correlated with years of education that was fixed until adolescence (i.e. 20 s). MoCA was significantly correlated with current age (<em>r</em>=−0.401, <em>p</em> = 0.005) and UPDRS part III (<em>r</em>=−0.374, <em>p</em> = 0.009), both of which continue to progress gradually after onset of PD. In multiple regression analyses, these correlations were significant and independent.</div></div><div><h3>Conclusion</h3><div>Premorbid and current intellectual performance reflect different background factors in patients with PD.</div></div>\",\"PeriodicalId\":72129,\"journal\":{\"name\":\"Aging and health research\",\"volume\":\"5 1\",\"pages\":\"Article 100221\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging and health research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667032125000022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and health research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667032125000022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在帕金森病(PD)的早期阶段,特别是在运动症状出现之前,人们对靶向治疗PD越来越感兴趣。认知功能障碍是帕金森病的一种非运动症状,而日本版的国家成人阅读测试(JART)是一种有效的评估病前智商(IQ)的方法。因此,JART的结果和PD发病后的当前认知评估可能反映了不同的背景因素。该研究的目的是比较使用JART评估病前智力表现和PD发病后当前认知功能的相关因素。方法当前运动症状(统一帕金森病评定量表;UPDRS Part III)和认知功能(蒙特利尔认知评估;对48例PD患者的MoCA进行了评估。用JART估计病前智商(言语智商:VIQ,表现智商:PIQ,全量表智商:FIQ)。计算背景因素(当前年龄、受教育年限、UPDRS第三部分和左旋多巴处方药物等效剂量(LED))与MoCA评分和估计智商的Spearman相关系数。结果估计VIQ (r= 0.451, p = 0.001)、PIQ (r= 0.445, p = 0.002)和FIQ (r= 0.453, p = 0.001)与固定至青春期(即20 s)的受教育年限显著相关,MoCA与当前年龄(r= - 0.401, p = 0.005)和UPDRS第三部分(r= - 0.374, p = 0.009)显著相关,两者在PD发病后继续逐渐进展。在多元回归分析中,这些相关性是显著且独立的。结论PD患者的发病前和当前智力表现反映了不同的背景因素。
Premorbid and current intellectual performance reflects different backgrounds in patients with Parkinson's disease
Background
There is growing interest in targeting Parkinson's Disease (PD) at an earlier stage, especially before emergence of motor symptoms. Cognitive dysfunction is a non-motor symptom in PD, whereas the Japanese version of the National Adult Reading Test (JART) is a validated battery to estimate the premorbid intellectual quotient (IQ). Therefore, the results of JART and current cognitive assessment after onset of PD may reflect different background factors. The goal of the study was to compare factors correlated with estimated premorbid intellectual performance using JART and current cognitive function after onset of PD.
Methods
Current motor symptoms (Unified Parkinson's Disease Rating Scale; UPDRS Part III) and cognitive function (Montreal Cognitive Assessment; MoCA) were assessed in 48 patients with PD. Premorbid IQs (verbal IQ: VIQ, performance IQ: PIQ, and full scale IQ: FIQ) were estimated using JART. Spearman correlation coefficients were calculated for background factors (current age, years of education, UPDRS Part III, and levodopa equivalent dose of prescribed drugs (LED)) with MoCA scores and estimated IQs.
Results
Estimated VIQ (r = 0.451, p = 0.001), PIQ (r = 0.445, p = 0.002) and FIQ (r = 0.453, p = 0.001) were significantly correlated with years of education that was fixed until adolescence (i.e. 20 s). MoCA was significantly correlated with current age (r=−0.401, p = 0.005) and UPDRS part III (r=−0.374, p = 0.009), both of which continue to progress gradually after onset of PD. In multiple regression analyses, these correlations were significant and independent.
Conclusion
Premorbid and current intellectual performance reflect different background factors in patients with PD.