早发性结直肠癌的肿瘤“年龄”

IF 42.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-02-06 DOI:10.1016/j.cell.2024.12.003

Gianluca Mauri, Giorgio Patelli, Giovanni Crisafulli, Salvatore Siena, Alberto Bardelli

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引用次数: 0

摘要

早发结直肠癌（EO-CRC）的发病率正在激增，到 2030 年，三分之一的结直肠癌患者将在通常推荐的 50 岁筛查年龄之前发病。EO-CRC 达到转移阶段所需的时间尚不清楚，但这一知识对于定制早期诊断筛查策略至关重要。在此，我们将讨论定义 EO-CRC 的一个关键生物学特征如何成为保护年轻人免受令人震惊且可能是前所未有的肿瘤流行的核心。

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Tumor “age” in early-onset colorectal cancer

The incidence of early-onset colorectal cancer (EO-CRC) is surging, and by 2030, one-third of all CRCs will occur before the commonly recommended screening age of 50 years. The time required for EO-CRC to reach the metastatic stage is unknown, yet this knowledge is critical to tailor early-diagnosis screening strategies. Here, we discuss how defining a key biological feature of EO-CRC may be central to protecting young adults from an alarming and probably unprecedented tumor epidemic.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.