出生前干细胞教育：来自母亲细菌的礼物

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-02-06 DOI:10.1016/j.stem.2025.01.009

Chenyan Huang, Ai Ing Lim

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引用次数: 0

摘要

母体肠道菌群在怀孕期间发生显著变化，在后代发育中起着关键作用。在这一期中，Dang等人证明，在怀孕期间修改母体肠道微生物组可以通过mTOR途径塑造后代的神经和肠道干细胞，并对其功能产生长期影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pre-birth stem cell education: A gift from mother’s bugs

The maternal gut microbiota undergoes significant changes during pregnancy and plays a pivotal role in offspring development. In this issue, Dang et al. demonstrate that modifying the maternal gut microbiome during pregnancy shapes offspring neural and intestinal stem cells via the mTOR pathway, with long-lasting effects on their functions.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.