迈向生命合成的路线图

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2025-03-13 DOI:10.1016/j.chempr.2024.102399

Christine M.E. Kriebisch , Olga Bantysh , Lorena Baranda Pellejero , Andrea Belluati , Eva Bertosin , Kun Dai , Maria de Roy , Hailin Fu , Nicola Galvanetto , Julianne M. Gibbs , Samuel Santhosh Gomez , Gaetano Granatelli , Alessandra Griffo , Maria Guix , Cenk Onur Gurdap , Johannes Harth-Kitzerow , Ivar S. Haugerud , Gregor Häfner , Pranay Jaiswal , Sadaf Javed , Job Boekhoven

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引用次数: 0

摘要

几个世纪以来，非生命物质合成生命的问题一直困扰着科学家，也令他们产生分歧。这一大胆的目标旨在揭示生命的基本原则，并利用生命的独特特征，如韧性、可持续性和进化能力。合成生命不仅仅是一个学术上的里程碑——它有可能彻底改变生物技术、医学和材料科学。尽管合成生物学、系统化学和生物物理学领域已经在合成生命方面取得了巨大的进步，但这些进步一直受到社会、哲学和技术挑战的阻碍，例如目标模糊、跨学科努力不一致、不完全解决公众和伦理问题。我们的观点基于与来自世界各地的科学家在为期两周的研讨会上的讨论，为生命的合成提供了一个路线图。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A roadmap toward the synthesis of life

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A roadmap toward the synthesis of life

The synthesis of life from non-living matter has captivated and divided scientists for centuries. This bold goal aims at unraveling the fundamental principles of life and leveraging its unique features, such as its resilience, sustainability, and ability to evolve. Synthetic life represents more than an academic milestone—it has the potential to revolutionize biotechnology, medicine, and materials science. Although the fields of synthetic biology, systems chemistry, and biophysics have made great strides toward synthetic life, progress has been hindered by social, philosophical, and technical challenges, such as vague goals, misaligned interdisciplinary efforts, and incompletely addressing public and ethical concerns. Our perspective offers a roadmap toward the synthesis of life based on discussions during a 2-week workshop with scientists from around the globe.

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.