多种变构机制抑制PRC2活性基因的活性

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-02-06 DOI:10.1038/s41594-025-01487-8

Evan J. Worden

引用次数: 0

摘要

prc2依赖性H3K27甲基化必须从活性基因中排除，以支持适当的转录程序。PRC2与核小体底物结合的结构包含与活性转录相关的组蛋白修饰，解释了PRC2如何在活性基因中被抑制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Multiple allosteric mechanisms suppress PRC2 activity at active genes

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Multiple allosteric mechanisms suppress PRC2 activity at active genes

PRC2-dependent H3K27 methylation must be excluded from active genes to support appropriate transcriptional programs. Structures of PRC2 bound to nucleosome substrates containing histone modifications associated with active transcription explain how PRC2 is inhibited at active genes.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.