Vithurithra Tharmapalan, Miriam Du Marchie Sarvaas, Michael Bleichert, Martina Wessiepe, Wolfgang Wagner
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Senolytic compounds reduce epigenetic age of blood samples in vitro.
Senolytic drugs raise the expectation that they can specifically eliminate a subset of senescent cells in a given tissue. In this study, we have exemplarily analyzed if a 3-day treatment of human blood samples in vitro would reduce age-associated biomarkers, with a particular focus on epigenetic age-predictions. Of eight tested compounds, JQ1, RG7112, nutlin-3a, and AMG232 reduced epigenetic age, indicating that this approach may be useful in drug screening for senolytic compounds.
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