Sheila Piccoli Garcia , Felipe Vogt Cureau , Fernando de Quadros Iorra , Leonardo G. Bottino , Laura E. R. C. Monteiro , Gabriel Leivas , Daniel Umpierre , Beatriz D. Schaan
{"title":"Effects of exercise training and physical activity advice on HbA1c in people with type 2 diabetes: A network meta-analysis of randomized controlled trials","authors":"Sheila Piccoli Garcia , Felipe Vogt Cureau , Fernando de Quadros Iorra , Leonardo G. Bottino , Laura E. R. C. Monteiro , Gabriel Leivas , Daniel Umpierre , Beatriz D. Schaan","doi":"10.1016/j.diabres.2025.112027","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>To compare the magnitude of the benefit of different exercise modalities on glycemic control, including aerobic training (AT), resistance training (RT), combined training (CT), high-intensity interval training (HIIT) and physical activity advice.</div></div><div><h3>Methods</h3><div>A network <em>meta</em>-analysis was conducted. Seven databases were searched from inception to May 2024. We included randomized clinical trials of at least 12 weeks’ duration evaluating different types of physical exercise and physical activity advice to reduce HbA1c in people with type 2 diabetes.</div></div><div><h3>Results</h3><div>158 studies (17,059 participants) were included. Compared with the control group, all types of exercise were associated with lower HbA1c: HIIT [−0.61 % (95 % CrI −0.84; −0.37)], CT [−0.58 % (95 % CrI −0.73; −0.42], AT [−0.58 % (95 % CrI −0.70; −0.45)], RT [−0.40 % (95 % CrI −0.59; −0.21)] and physical activity advice [−0.35 % (95 % CrI −0.53; −0.16)]. HIIT was the most effective treatment for HbA1c reduction (SUCRA = 82 %), followed by CT (SUCRA = 77 %), AT (SUCRA = 76 %), RT (SUCRA = 37 %) and physical activity advice (SUCRA = 29 %).</div></div><div><h3>Conclusions</h3><div>HIIT was associated with the greatest reduction in HbA1c. Physical activity advice, which is easy to implement, accessible and unsupervised, should also be offered to people with type 2 diabetes to improve glycemic control.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112027"},"PeriodicalIF":6.1000,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes research and clinical practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168822725000415","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Effects of exercise training and physical activity advice on HbA1c in people with type 2 diabetes: A network meta-analysis of randomized controlled trials
Aims
To compare the magnitude of the benefit of different exercise modalities on glycemic control, including aerobic training (AT), resistance training (RT), combined training (CT), high-intensity interval training (HIIT) and physical activity advice.
Methods
A network meta-analysis was conducted. Seven databases were searched from inception to May 2024. We included randomized clinical trials of at least 12 weeks’ duration evaluating different types of physical exercise and physical activity advice to reduce HbA1c in people with type 2 diabetes.
Results
158 studies (17,059 participants) were included. Compared with the control group, all types of exercise were associated with lower HbA1c: HIIT [−0.61 % (95 % CrI −0.84; −0.37)], CT [−0.58 % (95 % CrI −0.73; −0.42], AT [−0.58 % (95 % CrI −0.70; −0.45)], RT [−0.40 % (95 % CrI −0.59; −0.21)] and physical activity advice [−0.35 % (95 % CrI −0.53; −0.16)]. HIIT was the most effective treatment for HbA1c reduction (SUCRA = 82 %), followed by CT (SUCRA = 77 %), AT (SUCRA = 76 %), RT (SUCRA = 37 %) and physical activity advice (SUCRA = 29 %).
Conclusions
HIIT was associated with the greatest reduction in HbA1c. Physical activity advice, which is easy to implement, accessible and unsupervised, should also be offered to people with type 2 diabetes to improve glycemic control.
期刊介绍:
Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.