We have developed a highly sensitive fiber optic sensor that can measure temperature and pressure. The sensor comprises two Fabry–Perot interferometers (FPIs), FPI1 and FPI2, connected in parallel. FPI1 is composed of single mode fiber (SMF)—capillary—SMF spliced together, with a ventilation hole on the capillary. FPI2 is composed of SMF—capillary—SMF, and the capillary is filled with polyimide (PI). It is found that FPI1 is almost insensitive to temperature, but sensitive to air pressure. FPI2 is sensitive to temperature, but not sensitive to pressure. When the free spectra range (FSR) of FPI1 and FPI2 approaches twice the relationship, they are connected in parallel to form a first-order harmonic vernier effect (HVE). When the HVE sensor is used for air pressure sensing, FPI1 is the sensing cavity and FPI2 is the reference cavity. When the HVE sensor is used for temperature sensing, FPI2 is the sensing cavity and FPI1 is the reference cavity. The experimental results showed that the sensitivities of the pressure and temperature of the HVE sensor are 76.71 nm/MPa and 113.29 nm/ °C, respectively. This is currently the highest temperature sensitivity reported in literature. The accuracy of the obtained intersection point in HVE sensor is higher and than that of that of traditional Vernier effect. In addition, the FSR relationship required to form HVE is easier to achieve. By utilizing the temperature and air pressure sensitivities of FPI1 or FPI2, as well as that of the HVE sensor, a sensitivity measurement matrix can be formed to achieve simultaneous measurement of temperature and air pressure.