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IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2025-02-05 DOI:10.1016/j.jff.2025.106695

Dandan Liu , Hewei Qin , Guanghua Liu , Yang Gao , Yu Guo

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引用次数: 0

摘要

中药黄芪具有益气活血的功效，临床上常用于治疗各种心血管疾病。黄芪不仅是一种中药，现在还被广泛应用于各种保健食品中。黄芪皂苷 IV 是黄芪中含量最高的有效成分。此外，黄芪皂苷 IV 还具有调节血脂和抗氧化的药理潜力。通过建立高脂喂养载脂蛋白E-/-小鼠强直性脊柱炎模型和氧化-LDL诱导的血管内皮细胞脂质损伤模型，确定了黄芪皂苷 IV 的血管保护和抗软化作用。血脂谱（TC、TG、LDL-C、HDLC）、HE和局部油红O显示，黄芪皂苷IV治疗后动脉粥样硬化病理损伤和脂质沉积减少。黄芪皂苷 IV 还能增加 FTH1 和 p62 的表达，降低 NCOA4 和 Beclin1 的表达，并通过激活 Nrf2 抑制铁蛋白自噬。同时，当 ML385 抑制 Nrf2 时，黄芪皂苷 IV 可减少二价铁的表达，抑制铁死亡相关因子（FTH1、FTL、FPN、ACSL4），缓解铁代谢紊乱和 ROS 过度产生。总之，这些研究结果表明，黄芪皂苷 IV 可以通过激活 Nrf2 来调节依赖于自噬的 NCOA4 和 FTH1 的表达，从而抑制自噬。

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Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2

The Chinese medicine Astragalus mongholicus Bunge has the effect of benefiting vital energy and activating blood circulation, and is commonly used clinically in the treatment of various cardiovascular diseases. Astragalus is not only a kind of traditional Chinese medicine, but is now also widely used in various kinds of health food. Astragaloside IV is the most abundant active ingredient in this herb. In addition, astragaloside IV has lipid-modulating and antioxidant pharmacological potential. The vasoprotective and anti-ferroptosis effects of astragaloside IV were determined by establishing a high-fat-fed ApoE^−/− mouse model of AS and an ox-LDL-induced model of lipid damage in VECs. Lipid profile (TC, TG, LDL-C, HDLC), HE and local oil red O showed a reduction in atherosclerotic pathological damage and lipid deposition after astragaloside IV treatment. Astragaloside IV was then able to increase FTH1 and p62 expression, decrease NCOA4 and Beclin1 expression, and inhibit ferritin autophagy by activating Nrf2. Meanwhile, when ML385 inhibits Nrf2, astragaloside IV can diminish the expression of divalent iron, suppress iron death-related factors (FTH1, FTL, FPN, ACSL4), and alleviate disorders in iron metabolism and the overproduction of ROS. Collectively, these findings suggest that astragaloside IV can regulate autophagy-dependent NCOA4 and FTH1 expression through activation of Nrf2, thereby inhibiting autophagy.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.