bug编辑的威力和危险

IF 3.2 2区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Insect Biochemistry and Molecular Biology Pub Date : 2025-02-01 DOI:10.1016/j.ibmb.2024.104253

Helena Araujo

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引用次数: 0

摘要

半翅目的锥蝽属昆虫是被忽视的恰加斯病的病媒，该病在美洲造成巨大的健康负担。病媒控制已被认为是防治疾病传播的一个基本方面。然而，除了使用杀虫剂之外，还没有开发出针对这些昆虫的转基因或基因编辑工具，限制了生物防治策略的广泛使用。在这里，我提出了一个个人的帐户，试图开发基因编辑工具的三角蝽。我强调我们面临的主要挑战，我们为克服这些障碍所做的努力，以及前面仍然存在的障碍。我没有提供任何神奇的路径来引导你穿越接吻虫基因编辑的危险之地，而是列出一些我们所学到的规则，可能有助于你的旅程轻松。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The powers and perils of bug editing

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The powers and perils of bug editing

Triatomine insects of the Hemiptera order are vectors of the neglected Chagas disease, that inflicts a great health burden in the Americas. Vector control has been recognized as a fundamental aspect to fight disease spread. However, besides the use of insecticides, no transgenic or gene editing tools have been developed for these insects, limiting the widespread use of biological control strategies. Here I present a personal account in trying to develop gene editing tools for triatomines. I highlight the major challenges we have faced, the efforts we have made to overcome these obstacles, and the hurdles that still lie ahead. I deliver no magic path to guide you through the perilous land of kissing bug gene editing but rather lay down a few rules we have learned that may help ease your journey.

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来源期刊

Insect Biochemistry and Molecular Biology 生物-昆虫学

CiteScore

7.40

自引率

5.30%

发文量

105

审稿时长

40 days

期刊介绍： This international journal publishes original contributions and mini-reviews in the fields of insect biochemistry and insect molecular biology. Main areas of interest are neurochemistry, hormone and pheromone biochemistry, enzymes and metabolism, hormone action and gene regulation, gene characterization and structure, pharmacology, immunology and cell and tissue culture. Papers on the biochemistry and molecular biology of other groups of arthropods are published if of general interest to the readership. Technique papers will be considered for publication if they significantly advance the field of insect biochemistry and molecular biology in the opinion of the Editors and Editorial Board.