东非社区糖尿病植物性治疗的系统综述

Q3 Pharmacology, Toxicology and Pharmaceutics

Phytomedicine Plus Pub Date : 2025-02-01 DOI:10.1016/j.phyplu.2024.100717

Nancy Bonareri Mitaki , Ilemobayo Victor Fasogbon , Onyinye Vivian Ojiakor , Wusa Makena , Emmanuel O. Ikuomola , Reuben Samson Dangana , Ibe Micheal Usman , Ekom Monday Etukudo , Augustine Oviosun , Swase Dominic Terkimbi , Elizabeth Bessy Umoren , Angela Mumbua Musyoka , Solomon A Mbina , Esther Ugo Alum , Ibrahim Babangida Abubakar , Godson Emeka Anyanwu , Patrick Maduabuchi Aja

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引用次数: 0

摘要

糖尿病是一个严重的全球性健康问题，在东非尤为普遍。生活方式因素影响糖尿病的发病率、死亡率和发病率。药用植物具有抗糖尿病特性的植物化学物质。目的本系统综述评估了植物疗法治疗东非共同体（EAC）糖尿病的疗效、效率、安全性和可行性。方法利用PubMed、Scopus和Web of Science数据库进行文献检索。我们将搜索限制在同行评议的英文文章、临床前模型和干预研究中，这些研究报告了药用植物在糖尿病治疗中的应用，特别是在EAC中。本文遵循系统评价和荟萃分析指南（PRISMA） 2020。两名审稿人独立进行数据收集和质量评估。我们从数据库中检索到465篇文章，并审查了8篇符合本研究纳入标准的文章。结果鉴定出8种药用植物：麻花、杨梅花、花椒、小檗、茯苓、黄花、黄花、黄花、黄花、黄花。我们从文献中提取和分析信息，发现7种药用植物通过其作用机制降低血糖水平和胰岛素敏感性。结论这些药用植物主要含有生物碱、单宁和黄酮类化合物，可能与它们的降血糖作用有关。山参籽提取物对高血糖的控制效果较差。需要更多的临床前研究来调查植物疗法在EAC糖尿病管理中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community

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A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community

Background Information

Diabetes is a serious global health issue that is particularly common in East Africa. Lifestyle factors influence the incidence, mortality, and morbidity of diabetes. Medicinal plants have phytochemicals with anti-diabetic properties.

Purpose

This systematic review assesses the efficacy, efficiency, safety, and feasibility of phytotherapy in the treatment of diabetes in the East African Community (EAC).

Methods

we conducted a comprehensive literature search using PubMed, Scopus, and Web of Science databases. We limited our search to peer-reviewed English articles, preclinical models, and intervention studies reporting the use of medicinal plants in the treatment of diabetes, particularly in EAC. This article follows the Guidelines for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Two reviewers independently performed data collection and quality assessment. We retrieved 465 articles from the database and reviewed eight articles that met the inclusion criteria for this study.

Results

we identified eight medicinal plants: Maerua decumbens, Rotheca myricoides (Hochst), Piper capence, Berberis holstii, Polyscias fulva (Hiern) Harms, Lippia javanica, Caesalpina bonducella, and Securinega virosa. We extracted and analyzed information from the literature and showed that seven medicinal plants reduce blood sugar levels and insulin sensitivity through their mechanism of action.

Conclusion

The phytochemical properties of these medicinal plants, mainly containing alkaloids, tannins, and flavonoids, may contribute to their hypoglycemic effects. Caesalpinia bonducella seed extract is less effective in controlling high blood sugar. More preclinical studies are needed to investigate the potential of phytotherapy in the management of diabetes in EAC.

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