长期磷酸盐暴露对大菱鲆幼鱼的影响：生长、代谢和适应性反应

IF 4.9 3区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Marine pollution bulletin Pub Date : 2025-02-05 DOI:10.1016/j.marpolbul.2025.117618

Xin Li , Lele Wu , Jiale Zhou , Yaolin Li , Ting Qi , Xiefa Song , Zongcheng Song , Xian Li

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引用次数: 0

摘要

磷酸盐（PO₄3−p）是导致自然生态系统水体富营养化的主要污染物之一，也是水资源管理中被忽视的因素。水生生物对磷酸盐的毒理学反应机制尚不清楚。本研究采用0 （CK）、60 （LP）和120 mg/L （HP）的PO₄3−-P处理大菱鲆幼鱼60天。代谢组学分析表明，LP条件下，幼鱼可以通过调节半乳糖代谢途径提供能量来补偿生长，而HP条件下，幼鱼会破坏谷胱甘肽代谢途径，引起不可逆的氧化应激损伤。此外，综合生物标志物反应版本2 （IBRV2）分析显示，幼鱼逐渐适应LP，而HP组的血浆葡萄糖、甘油三酯和其他生物标志物仍显著高于CK组。这些发现揭示了磷酸盐对鱼类的潜在毒性机制，为磷酸盐的安全监测和合理控制提供了必要的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Long-term phosphate exposure effects on juvenile turbot (Scophthalmus maximus): Growth, metabolism, and adaptive responses

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Long-term phosphate exposure effects on juvenile turbot (Scophthalmus maximus): Growth, metabolism, and adaptive responses

Phosphate (PO₄³⁻-P) is one of the main pollutants contributing to water eutrophication in natural ecosystems and is also a neglected factor in water management. The toxicological response mechanisms of aquatic organisms to phosphate remain unclear. In the current study, juvenile Scophthalmus maximus were exposed to 0 (CK), 60 (LP), and 120 mg/L (HP) of PO₄³⁻-P for 60 days. Metabolomics analysis indicated that juveniles could compensate for growth by adjusting the galactose metabolic pathway to supply energy under LP, while they disrupted the glutathione metabolic pathway, inducing irreversible oxidative stress damage under HP. Furthermore, integrated biomarker response version 2 (IBRV2) analysis showed that juveniles gradually adapted to LP, while plasma glucose, triglycerides, and other biomarkers in the HP group remained significantly higher than in the CK group. These findings reveal the potential toxicity mechanism of phosphate to fish and provide necessary data for the safety monitoring and reasonable control of phosphate.

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来源期刊

Marine pollution bulletin 环境科学-海洋与淡水生物学

CiteScore

10.20

自引率

15.50%

发文量

1077

审稿时长

68 days

期刊介绍： Marine Pollution Bulletin is concerned with the rational use of maritime and marine resources in estuaries, the seas and oceans, as well as with documenting marine pollution and introducing new forms of measurement and analysis. A wide range of topics are discussed as news, comment, reviews and research reports, not only on effluent disposal and pollution control, but also on the management, economic aspects and protection of the marine environment in general.