饮食失调和心血管疾病：一项荟萃分析的系统综述

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2025-01-28 DOI:10.1016/j.ejpsy.2024.100274

Cristiane Buzanello-Donin , Monica Augusta Mombelli , Márcia Rosângela Buzanello , Clenise Maria Reis Capellani dos Santos , Cassia Cristina Paes de Almeida , Rogério da Luz , Miguel Morita Fernandes da Silva

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引用次数: 0

摘要

背景与目的通过文献综述来评估饮食失调（ED）、心血管结局和全因死亡率之间的关系。方法纳入了对成人或青少年患者的死亡率（或心脏结果）与ed之间的关联进行测量的观察性研究。参考PubMed、Web of Science、EMBASE、Livivo、Scopus、PsycINFO、Lilacs等数据库。采用随机效应对meta分析中主要研究的结果进行分组，使用危险比（HR）作为关联的衡量标准。结果对50263例ED患者的荟萃分析显示，与对照组相比，患者的全因死亡风险更高。与其他ED相比，厌食症（AN）的相关全因死亡风险更高(AN: HR 5.38；95% CI 4.42 ~ 6.56；狂欢ED: HR 2.48；95% CI 1.13 - 5.46；暴食症：HR 2.21；95% CI 1.70 - 2.87)。此外，一项研究表明贪食症与患心血管疾病的风险增加之间存在关联(HR 4.25；95% CI 2.98 - 6.07)，另一项研究显示，暴食症患者的心血管事件风险高于健康对照组(HR 1.4；95% CI 0.7 - 2.8)。最后，AN患者的心血管事件风险更高(HR 10.4；一项研究表明，与健康对照相比，95%可信区间为2.6至41.6)。结论：ED与全因死亡率之间存在关联，其中an风险最高，其次是暴食性ED和贪食症。

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Eating disorders and cardiovascular outcomes: A systematic review with meta-analysis

Background and objective

To conduct a literature review to assess the association between eating disorders (ED), cardiovascular outcomes and all-cause mortality.

Methods

Observational studies that presented a measure of association between mortality (or cardiac outcomes) and EDs in adult or adolescent patients were included. The databases PubMed, Web of Science, EMBASE, Livivo, Scopus, PsycINFO and Lilacs were consulted. The random effect was adopted to group the findings of the primary studies in the meta-analysis using the Hazzard Ratio (HR) as a measure of association.

Results

The meta-analysis with 50,263 patients with ED showed a higher risk of mortality from all causes in patients compared to controls. The associated risk of death from all causes was higher with anorexia (AN) compared to other ED (AN: HR 5.38; 95 %CI 4.42 to 6.56; binge ED: HR 2.48; 95 %CI 1.13 to 5.46; bulimia: HR 2.21; 95 %CI 1.70 to 2.87). Additionally, one study demonstrated an association between bulimia and an increased risk of developing cardiovascular disease (HR 4.25; 95 %CI 2.98 to 6.07) and another study showed a higher risk of cardiovascular events in people with bulimia than in healthy controls (HR 1.4; 95 %CI 0.7 to 2.8). Finally, a higher risk of cardiovascular events in people with AN (HR 10.4; 95 %CI 2.6 to 41.6) was demonstrated in one study, when compared to healthy controls.

Conclusions

There is an association between EDs and all-cause mortality, with AN being associated with the highest risk, followed by binge ED and bulimia.

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.