标题乌头中一个新的二萜类生物碱

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-01 DOI:10.1016/j.phytol.2024.12.002

Cheng-En Fu , Gui-Fang Li , Guo-Qing Sun , Shuai Huang , Lin Chen , Xian-Li Zhou

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引用次数: 0

摘要

从臭头乌头（Aconitum scaposum Franch）干块根中分离得到一种新的碱型c20 -二萜生物碱（scaposum A）和12个已知化合物（2 ~ 13个），并对其进行了IR、HR-ESI-MS和NMR等光谱分析。所有化合物均为首次从该植物中分离得到，并检测了它们对Sf9和4T1细胞的抗增殖作用，对lps诱导的BV2和RAW264.7细胞NO生成的抑制作用，以及对电鳗乙酰胆碱酯酶（eeAChE）的抑制作用。结果表明，化合物8（81.26 %）和11（80.99 %）在100 μM下对4T1细胞具有抑制增殖作用，与喜树碱（81.61 %）相当，化合物7（30 μM）对lps诱导的BV2细胞释放NO具有中等抑制作用，且对eeAChE具有中等抑制作用。

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A new diterpenoid alkaloid from the Aconitum scaposum

A new atisine-type C₂₀-diterpenoid alkaloid (scaposum A) and twelve known compounds (2–13) were isolated from the dried tuberous roots of Aconitum scaposum Franch and characterized by spectroscopic analyses such as IR, HR-ESI-MS and NMR. All compounds were isolated from this plant for the first time and tested for their anti-proliferative effects on Sf9 and 4T1 cells, inhibition of NO production from LPS-induced BV2 and RAW264.7 cells, and inhibition of acetylcholinesterase from Electrophorus electricus (eeAChE). The results showed that compounds 8 (81.26 %) and 11 (80.99 %) exhibited anti-proliferative effects on 4T1 cells at 100 μM, which were comparable to that of camptothecin (81.61 %), and compound 7 (30 μM) exhibited a moderate inhibitory effect on NO release from LPS-induced BV2 cells, in addition to the moderate inhibitory effect of all compounds on the eeAChE.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.