临床表达的共情和反安慰剂缓解信息对乳腺癌患者积极化疗期间焦虑和副作用的影响：临床可行性研究

PEC innovation Pub Date : 2025-01-15 DOI:10.1016/j.pecinn.2025.100373

Lara C. Gröschel , Fiona T. Brosig , Marcel Soesan , Katherina T. Vourtsis , Mirte van der Spek , Elise Sluiter , Liesbeth M. van Vliet

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引用次数: 0

摘要

目的通过标准化信息视频传递反安慰剂缓解信息和临床表达共情对乳腺癌患者化疗期间心理和副作用结局的主要作用和交互作用，建立一项试点研究。此外，我们旨在反思干预措施的可行性（可接受性、实用性和整合性），为未来的后续研究提供信息。方法：通过一项临床原理验证随机对照试验，接受化疗的女性乳腺癌患者观看了四个视频中的一个，这些视频的反安慰剂缓解信息（+/−）和临床医生表达的同理心（+/−）水平不同。由于样本量较小（n = 27），我们使用描述性和招募性数据来评估效果并反思可行性。结果这些干预措施在我们的小样本中似乎产生有限的效果。可行性思考主要集中在实践层面，如使用更具通用性的视频，优化流程等。结论本研究显示视频干预效果有限。它揭示了招聘的挑战，而在纳入后的可接受性很高。展望未来，面对面的医患互动仍然很重要，同时谨慎地探索现代技术进步的潜在好处，确保在实施前对其效果进行彻底的测试。这项研究标志着在临床环境中利用数字干预来提高癌症患者预后的创新方法。

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The effect of clinician-expressed empathy and nocebo-alleviating information on breast-cancer-patients' anxiety and side effects during active chemotherapy: A clinical feasibility study

Objective

We set up a pilot-study to investigate main and interaction effects of nocebo-alleviating information and clinician-expressed empathy delivered via a standardized information-video on breast cancer patients' psychological and side effect outcomes during chemotherapy. Additionally, we aimed to reflect on the feasibility of the intervention (acceptability, practicality and integration) to inform future – follow-up – studies.

Methods

Using a clinical proof-of-principle randomized controlled trial, female breast cancer patients undergoing chemotherapy viewed one of four videos, varying in the level of nocebo-alleviating information(+/−) and clinician-expressed empathy(+/−). Due to the small sample size (n = 27), descriptive and recruitment data were utilized to evaluate effects and reflect on feasibility.

Results

The interventions appeared to yield limited effects on our small sample. Feasibility reflections mainly focused on the practical level, such as the use of more generalizable videos and optimizing the flow.

Conclusion

The study showed limited effects of the video intervention. It revealed recruitment challenges, while acceptability was high after inclusion. Moving forward, face-to-face clinician-patient interactions remain important, while cautiously exploring the potential benefits of modern technological advancements, ensuring thorough testing of their effects before implementation.