非病变性癫痫患儿淋巴系统功能改变的弥散核磁共振分析

Q4 Neuroscience

Neuroimage. Reports Pub Date : 2025-01-30 DOI:10.1016/j.ynirp.2025.100237

Bixia Wu , Gengbiao Zhang , Yanting Wang , Hongyi Zheng , Hui Tan , Wenbin Zheng

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引用次数: 0

摘要

目的基于弥散张量成像（diffusion tensor imaging， DTI）数据，采用沿血管周围间隙DTI分析（DTI- alps）和自由水成像（free-water mapping）方法，探讨小儿磁共振成像（MRI）阴性非病变性癫痫（NLE）患者淋巴系统的功能及其与临床特征的关系。方法共纳入83例NLE患儿（平均年龄9.25±4.07岁）和45例健康对照（平均年龄9.36±3.89岁）。所有符合条件的患者均常规行3.0T MRI扫描，排除器质性病变，同时收集DTI数据。计算脑内阿尔卑斯指数和脑白质游离水分数体积（FW-WM），分析组间差异及相应参数与发病年龄、病程、发作频率、发作持续时间等临床指标的相关性。结果与HC组相比，NLE组左半球（ALPS- l, F = 4.415, p = 0.038）和右半球（ALPS- r, F = 12.673, p = 0.001）的ALPS指数明显降低。ALPS-L与发病年龄呈正相关（r = 0.322, p = 0.008），与FW-WM呈负相关(r = - 0.337, p <；0.001)。自由水图谱显示，NLE组的FW-WM明显高于HC组（F = 4.666, p = 0.033）。此外，FW-WM与发病年龄呈负相关(r = - 0.463, p <；0.001)，与NLE患儿癫痫发作控制呈正相关（r = 0.306, p = 0.012）。结论NLE患儿淋巴系统功能降低，其病理生理机制可能与脑内间质液清除和保留功能受损有关。DTI-ALPS和自由水成像是检查NLE儿童淋巴功能的有用的无创方法，FW-WM可能作为NLE儿童疾病进展和预测临床预后的影像学标志物。

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Diffusion MRI-based analysis of functional alterations of the glymphatic system in children with non-lesional epilepsy

Objective

Based on diffusion tensor imaging (DTI) data, we used DTI-analysis along the perivascular space (DTI-ALPS) and free-water mapping to investigate the function of the glymphatic system and its relationship with clinical features among pediatric patients with magnetic resonance imaging (MRI)-negative non-lesional epilepsy (NLE).

Methods

A total of 83 NLE children (mean age 9.25 ± 4.07 years) and 45 matched healthy controls (mean age 9.36 ± 3.89 years) were recruited. All eligible patients were routinely scanned by 3.0T MRI to rule out organic lesions, and DTI data were collected at the same time. The ALPS index and fractional volume of free water in white matter (FW-WM) in the brain were calculated to analyze the differences between groups and the correlation between the corresponding parameters and clinical indicators such as age of onset, duration of the disease, seizure frequency, and seizure duration.

Results

The NLE group had significantly lower ALPS indexes in the left (ALPS-L, F = 4.415, p = 0.038) and right (ALPS-R, F = 12.673, p = 0.001) cerebral hemispheres compared to the HC group. ALPS-L was positively correlated with age of onset (r = 0.322, p = 0.008) and negatively correlated with FW-WM (r = −0.337, p < 0.001). Free-water mapping revealed substantially higher FW-WM in the NLE group compared to the HC group (F = 4.666, p = 0.033). Additionally, FW-WM was negatively correlated with age of onset (r = −0.463, p < 0.001) and positively associated with seizure control in children with NLE (r = 0.306, p = 0.012).

Conclusion

Children with NLE have reduced glymphatic system function, and the underlying pathophysiologic mechanisms may be due to impaired interstitial fluid clearance and retention in the brain. DTI-ALPS and free-water mapping are useful noninvasive approaches for examining glymphatic function in children with NLE, with the FW-WM potentially serving as an imaging marker for disease progression and predicting clinical prognosis in children with NLE.

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来源期刊

Neuroimage. Reports Neuroscience (General)

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

87 days