β-葡聚糖受体参与β-葡聚糖抗肿瘤活性的研究

Atsushi Iwai
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引用次数: 0

摘要

β-葡聚糖由β-(1,3)连接葡萄糖为主链组成(以下简称“β-葡聚糖”),被认为对健康有许多有益的潜在影响。在已知的有益作用中,β-葡聚糖最显著的作用是抗肿瘤作用。自20世纪中期以来,β-葡聚糖的抗肿瘤作用就已为人所知。在目前的癌症治疗中,免疫检查点抑制剂备受关注,预计β-葡聚糖联合给药将显示出更大的治疗效果。β-葡聚糖的抗肿瘤作用被认为与识别β-葡聚糖的受体密切相关。另一方面,除了众所周知的β-葡聚糖受体CR3(补体受体3)和dectin-1(树突状细胞相关c型凝集素-1)外,还有许多受体可以识别β-葡聚糖。本文对近年来报道的β-葡聚糖受体进行了综述,并讨论了β-葡聚糖抗肿瘤作用的分子机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Involvement of β-glucan receptors on the antitumor activity of β-glucans

Involvement of β-glucan receptors on the antitumor activity of β-glucans
β-glucans consisting of β-(1,3)-linked glucose as the main chain (hereafter simply called “β-glucan”) are suggested to have the potential for many beneficial effects on health. Among known beneficial effects, the most notable effect of β-glucan would be the antitumor effect. The antitumor effect of β-glucan has been known since the mid-twentieth century. In current cancer treatments where immune checkpoint inhibitors are attracting attention, it is expected that the combined administration of β-glucan will exhibit a greater therapeutic effect. The antitumor effect of β-glucan is believed to be closely linked to the receptors that recognize β-glucan. On the other hand, it has been clarified that there are many receptors for the recognition of β-glucan, in addition to CR3 (complement receptor 3) and dectin-1 (dendritic cell-associated C-type lectin-1), the well-known β-glucan receptors. This review focused on various β-glucan receptors reported previously and discusses the molecular mechanisms through which β-glucans exhibit antitumor effects.
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