中华头杉的重排和对映体生物碱

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-01-30 DOI:10.1016/j.tetlet.2024.155437

Jing Wu , Xin-Yu Liu , Mei-Fen Bao , Bao-Bao Shi , Ming-Xiang Li , Xiang-Hai Cai

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引用次数: 0

摘要

从头杉（Cephalotaxus sinensis）的枝条和叶片中分离得到3种未描述的生物碱（1-3）和30种已知的生物碱。通过综合光谱分析和ECD计算确定了新生物碱的结构。具有6/6/6/5环体系的Cephalosinine A(1)是一种新型的cephalalotaxus生物碱，可能是由同时分离的cephalalotaxone重排而成。Cephalolancine B(2)是第二种Cephalolancine骨架生物碱。（+）-乙酰头孢噻素β- n -氧化物(3)是头孢噻素对映体生物碱。研究了分离得到的单赤藓类生物碱对新霉素诱导HEI-OC-1细胞死亡的体外听力保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rearranged and enantiomeric alkaloids from Cephalotaxus sinensis

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Rearranged and enantiomeric alkaloids from Cephalotaxus sinensis

Three undescribed alkaloids (1–3) along with 30 known ones were isolated from the twigs and leaves of Cephalotaxus sinensis. The structures of the new alkaloids were determined through comprehensive spectroscopic analysis and ECD calculations. Cephalosinine A (1) with 6/6/6/5 ring system represents a new type of Cephalotaxus alkaloid, which might be formed through a rearrangement from simultaneously isolated cephalotaxinone. Cephalolancine B (2) was the second cephalolancine skeleton alkaloid. (+)-Acetylcephalotaxine β-N-oxide (3) was an enantiomeric Cephalotaxus alkaloid. The isolated homoerythrina-type alkaloids were evaluated for their in vitro hearing protective effects against neomycin-induced cell death in HEI-OC-1 cells.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.