巯基脲有机催化剂催化2-糠基酮与硝基烯烃的不对称ε-区域选择性共轭加成

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-01-30 DOI:10.1016/j.tetlet.2024.155392

Taro Koda , Hiroshi Akutsu , Mitsuaki Suzuki , Kosuke Nakashima , Shin-ichi Hirashima , Akihiro Yoshida , Tsuyoshi Miura , Takashi Yamanoi

引用次数: 0

摘要

采用吡咯烷-硫脲有机催化剂对硝基烯进行了2-糠基酮的非对称ε-区域选择性共轭加成反应，得到了高收率、高对映选择性的ε-区域选择性加成产物。本研究是2-糠基酮在硝基烯烃上的非对称ε-区域选择性共轭加成的第一个例子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst

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Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst

The asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a pyrrolidine–thiourea organocatalyst yielded ε-regioselective addition products in high yields with high enantioselectivities. This work represents the first example of asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.