亚硫酸盐杆菌sp. PM12的基因组分析揭示了其在甜菜碱代谢中的作用

IF 1.3 4区生物学 Q4 GENETICS & HEREDITY

Marine genomics Pub Date : 2025-01-22 DOI:10.1016/j.margen.2025.101167

Jun Li , Ya Ma , Ronghua Zhang , Nan Zhang

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引用次数: 0

摘要

甜菜碱是一种两性离子相容化合物，在自然界中分布广泛，在多种微生物中都有发现。它在渗透保护和单碳代谢中起着关键作用。从从马里亚纳海沟采集的深海样本中分离出革兰氏阴性需氧细菌PM12亚硫酸盐杆菌。在此，我们报道了菌株PM12的全基因组序列及其合成和分解甜菜碱的基因组特征。菌株PM12的基因组包含1条环状染色体（3,009,717 bp）和7个环状质粒。基因组分析表明，菌株PM12含有一组参与甜菜碱生物合成和生物降解的基因，表明其具有代谢甜菜碱的能力。本研究扩大了我们对海洋细菌驱动甜菜碱代谢的理解，并揭示了菌株PM12适应马里亚纳海沟极端环境的潜在策略。

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Genomic analysis of Sulfitobacter sp. PM12 reveals its role in betaine metabolism

Betaine is a zwitterionic compatible compound, which is widely distributed in nature and can be found in a variety of microorganisms. It plays key roles in osmotic protection and one‑carbon metabolism. Sulfitobacter sp. PM12, a Gram-negative and aerobic bacterium, was isolated from the deep-sea samples collected from the Mariana Trench. Here, we report the complete genome sequence of strain PM12 and its genomic characteristics to synthesize and catabolize betaine. The genome of strain PM12 contains one circular chromosome (3,009,717 bp) and seven circular plasmids. Genomic analysis showed that strain PM12 contained a set of genes involved in betaine biosynthesis and biodegradation, indicating that it possesses the ability to metabolize betaine. This study enlarges our understanding of the betaine metabolism driven by bacteria in the ocean, and reveals the potential strategy of the strain PM12 to adapt the extreme environments of the Mariana Trench.

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来源期刊

Marine genomics 生物-遗传学

CiteScore

3.60

自引率

5.30%

发文量

审稿时长

29 days

期刊介绍： The journal publishes papers on all functional and evolutionary aspects of genes, chromatin, chromosomes and (meta)genomes of marine (and freshwater) organisms. It deals with new genome-enabled insights into the broader framework of environmental science. Topics within the scope of this journal include: • Population genomics and ecology • Evolutionary and developmental genomics • Comparative genomics • Metagenomics • Environmental genomics • Systems biology More specific topics include: geographic and phylogenomic characterization of aquatic organisms, metabolic capacities and pathways of organisms and communities, biogeochemical cycles, genomics and integrative approaches applied to microbial ecology including (meta)transcriptomics and (meta)proteomics, tracking of infectious diseases, environmental stress, global climate change and ecosystem modelling.