电沉积Ti3C2Tx MXene纳米片上修饰的铂纳米粒子作为CA15-3检测的超灵敏生物传感器

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports Pub Date : 2024-12-26 DOI:10.1016/j.snr.2024.100278

Sepideh Shafaei , Rahim Mohammad-Rezaei , Balal Khalilzadeh , Ibrahim Isildak

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引用次数: 0

摘要

本研究报道了一种基于MXene纳米片修饰的铂纳米粒子的高效超灵敏生物传感器，用于检测CA15-3乳腺癌生物标志物。为了提高制备的生物传感器的准确性和可重复性，将MXene NSs和铂纳米粒子（PtNPs）电化学沉积在玻碳电极（MXene- pt /GCE）表面。MXene和PtNPs的协同作用使链霉亲和素和CA15-3抗体在电极表面的电导率提高、电子转移快、灵敏度提高和稳定性提高。电化学结果表明，MXene-Pt/GCE的电活性表面积为0.1345 cm2，明显大于GCE。所研制的CA15-3乳腺癌生物传感器的检出限为1 nU，线性范围为1 ~ 100 nU。基于这些数据，所提出的生物传感器具有独特的可重复性、稳定性和选择性，可以区分健康血清样本和乳腺癌患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection

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Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection

In this study, an efficient and ultrasensitive biosensor based on platinum nanoparticles decorated on MXene nanosheets (NSs) was reported for the detection of CA15–3 breast cancer biomarker. In order to increase the accuracy and reproducibility of the fabricated biosensor, MXene NSs and platinum nanoparticles (PtNPs) were electrochemically deposited on the surface of glassy carbon electrode (MXene-Pt/GCE). The synergistic effect of MXene and PtNPs caused an increased conductivity, fast electron transfers, amplified sensitivity and improved stabilization of streptavidin and CA15–3 antibody on the electrode surface. According to the electrochemical results, the electroactive surface area of MXene-Pt/GCE was obtained 0.1345 cm² which was remarkably more than GCE. The detection limit and linear range for the developed CA15–3 breast cancer biosensor were 1 nU and 1 to 100 nU, respectively. Based on the data, the proposed biosensor exhibited unique reproducibility, stability, and selectivity which can be differentiate between the healthy serum samples and patients suffering from breast cancer.

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来源期刊

Sensors and Actuators Reports Multiple-

CiteScore

9.60

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： Sensors and Actuators Reports is a peer-reviewed open access journal launched out from the Sensors and Actuators journal family. Sensors and Actuators Reports is dedicated to publishing new and original works in the field of all type of sensors and actuators, including bio-, chemical-, physical-, and nano- sensors and actuators, which demonstrates significant progress beyond the current state of the art. The journal regularly publishes original research papers, reviews, and short communications. For research papers and short communications, the journal aims to publish the new and original work supported by experimental results and as such purely theoretical works are not accepted.