{"title":"与COVID-19相关的儿童多系统炎症综合征（MIS-C）的临床特征：来自约旦的一项多中心观察性研究","authors":"Marwan Shalabi , Salam Ghanem , Iyad Al-Ammouri , Amirah Daher , Enas Al-zayadneh , Alaa Alsmadi , Mais Ayyoub , Samah Abughanam , Mariam Jabr , Montaha Al-Iede","doi":"10.1016/j.gloepi.2025.100185","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Multisystem inflammatory syndrome of childhood (MIS-C) is a newly recognized entity associated with COVID-19 in children. The objective was to describe the clinical course for 74 patients diagnosed with this disease.</div></div><div><h3>Methods</h3><div>A multicenter retrospective study including 5 major hospitals in Jordan was conducted. Data from children admitted with confirmed SARS-CoV-2 infection or were in close contact with confirmed cases were collected. Total of 74 patients were diagnosed with MIS-C. Clinical, laboratory, radiological and therapeutic data were collected by retrospective chart review.</div></div><div><h3>Results</h3><div>Fever, abdominal pain, hypoxia and other manifestation occurred. Cardiac findings were less common and did not include coronary findings. Treatments were mainly Corticosteroids and IVIG. No mortality was found in this series but serious disease occurred and some patients were admitted to Pediatric Intensive Care Unit.</div></div><div><h3>Conclusions</h3><div>This study described the epidemiology, clinical course, management, and outcome of MIS-C cases in Jordan. The findings were consistent with what has been described from other regions globally. There was a wide spectrum in the severity of presentation. Abdominal pain was more prevalent and some children were misdiagnosed as surgical acute abdomen.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"9 ","pages":"Article 100185"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan\",\"authors\":\"Marwan Shalabi , Salam Ghanem , Iyad Al-Ammouri , Amirah Daher , Enas Al-zayadneh , Alaa Alsmadi , Mais Ayyoub , Samah Abughanam , Mariam Jabr , Montaha Al-Iede\",\"doi\":\"10.1016/j.gloepi.2025.100185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Multisystem inflammatory syndrome of childhood (MIS-C) is a newly recognized entity associated with COVID-19 in children. The objective was to describe the clinical course for 74 patients diagnosed with this disease.</div></div><div><h3>Methods</h3><div>A multicenter retrospective study including 5 major hospitals in Jordan was conducted. Data from children admitted with confirmed SARS-CoV-2 infection or were in close contact with confirmed cases were collected. Total of 74 patients were diagnosed with MIS-C. Clinical, laboratory, radiological and therapeutic data were collected by retrospective chart review.</div></div><div><h3>Results</h3><div>Fever, abdominal pain, hypoxia and other manifestation occurred. Cardiac findings were less common and did not include coronary findings. Treatments were mainly Corticosteroids and IVIG. No mortality was found in this series but serious disease occurred and some patients were admitted to Pediatric Intensive Care Unit.</div></div><div><h3>Conclusions</h3><div>This study described the epidemiology, clinical course, management, and outcome of MIS-C cases in Jordan. The findings were consistent with what has been described from other regions globally. There was a wide spectrum in the severity of presentation. Abdominal pain was more prevalent and some children were misdiagnosed as surgical acute abdomen.</div></div>\",\"PeriodicalId\":36311,\"journal\":{\"name\":\"Global Epidemiology\",\"volume\":\"9 \",\"pages\":\"Article 100185\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global Epidemiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590113325000033\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590113325000033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的儿童多系统炎症综合征（multi - system inflammatory syndrome of childhood, MIS-C）是新发现的与COVID-19相关的儿童疾病。目的是描述74例诊断为这种疾病的患者的临床病程。方法对约旦5家主要医院进行多中心回顾性研究。收集了确诊感染SARS-CoV-2的住院儿童或与确诊病例密切接触的儿童的数据。共有74例患者被诊断为misc。临床，实验室，放射学和治疗资料收集回顾性图表审查。结果患者出现发热、腹痛、缺氧等症状。心脏方面的发现较少，不包括冠状动脉的发现。治疗主要是皮质类固醇和IVIG。本组病例均无死亡，但发生严重疾病，部分患者被送入儿科重症监护病房。结论本研究描述了约旦misc病例的流行病学、临床过程、处理和结局。这一发现与全球其他地区的情况一致。表现的严重程度有很大的差别。腹痛多见，部分患儿被误诊为外科急腹症。
Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan
Objective
Multisystem inflammatory syndrome of childhood (MIS-C) is a newly recognized entity associated with COVID-19 in children. The objective was to describe the clinical course for 74 patients diagnosed with this disease.
Methods
A multicenter retrospective study including 5 major hospitals in Jordan was conducted. Data from children admitted with confirmed SARS-CoV-2 infection or were in close contact with confirmed cases were collected. Total of 74 patients were diagnosed with MIS-C. Clinical, laboratory, radiological and therapeutic data were collected by retrospective chart review.
Results
Fever, abdominal pain, hypoxia and other manifestation occurred. Cardiac findings were less common and did not include coronary findings. Treatments were mainly Corticosteroids and IVIG. No mortality was found in this series but serious disease occurred and some patients were admitted to Pediatric Intensive Care Unit.
Conclusions
This study described the epidemiology, clinical course, management, and outcome of MIS-C cases in Jordan. The findings were consistent with what has been described from other regions globally. There was a wide spectrum in the severity of presentation. Abdominal pain was more prevalent and some children were misdiagnosed as surgical acute abdomen.
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