Design, synthesis and biological assessment of novel pyridopyrimidine and chromenopyridopyrimidine analogues

The important pharmacological and medicinal facts concerning chromenopyridopyrimidine and pyridopyrimidine compounds motivated us to condense our efforts into constructing novel derivatives with valuable biological properties. A series of new chromenopyridopyrimidine 2–4 and different substituted pyridopyrimidine derivatives 6–9 and 13 were synthesized in one pot three components base-catalyzed reaction of aminothiouracil 1 with various aldehydes and different active methylene compounds. Also, substituted pyridopyrimidines 10 and 11 were synthesized when thiouracil 1 reacted only with cinnamaldehyde and acetyl acetone. The synthesized compounds’ structure was verified by microanalysis and spectral data, the biological studies demonstrated antibacterial and antifungal activities against E. coli, Pseudomonas aeruginosa, S. aureus, and C. albicans.