研究γ -谷氨酰转移酶与同型半胱氨酸、铁蛋白和尿酸在II型糖尿病患者中的协同作用

Q3 Medicine

Endocrine and Metabolic Science Pub Date : 2024-12-12 DOI:10.1016/j.endmts.2024.100211

Simin Shirvani , Masomeh Halvaeezade , Maryam Avazzade , Morteza Golbashirzadeh , Atousa Moradzadegan

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引用次数: 0

摘要

背景和目的2型糖尿病（T2DM）是一个日益受到关注的公共卫生问题，氧化应激与其发病和进展有关。本研究评估了γ-谷氨酰转移酶（γ-GT）作为氧化应激标志物与同型半胱氨酸（Hcy）、尿酸（UA）和铁蛋白在T2DM患者中的协同作用，并与健康个体进行了比较。材料和方法本病例对照研究包括200名参与者，其中100名T2DM患者和100名年龄和性别匹配的健康人，来自Ahvaz Pasteur病理实验室。采用Cobas E411自动分析仪（ECL法）测定血清葡萄糖和铁蛋白水平，采用Pentra C400分析仪（光度法）测定γ-GT、Hcy和UA水平。采用XLSTAT和SPSS软件对数据进行分析。结果空腹血糖（FBS）、餐后2小时（2hpp）血糖水平与血清铁蛋白水平(P <；0.001, r = 0.419, P = 0.002, r = 0.290)，提示铁蛋白在T2DM发病中的作用。铁蛋白水平与γ-GT水平显著相关(P <；0.001, r = 0.359)，与T2DM患者Hcy （P = 0.001, r = 0.336）、UA （P = 0.02, r = 0.218）相关。结论本研究强调了氧化应激的作用以及γ-GT和铁蛋白在T2DM发展中的协同作用，强调了它们在临床实践中作为预测T2DM的成本效益和广泛应用的标志物的潜力。与以往研究单独关注氧化应激标志物不同，本研究独特地将γ-GT与Hcy、UA和铁蛋白结合起来，提供了T2DM患者氧化应激的综合评估。主里。氧化应激在T2DM中的作用：本研究探讨了氧化应激标志物，特别是γ-谷氨酰转移酶（γ-GT）和铁蛋白在2型糖尿病（T2DM）发展中的作用。与其他生物标志物的相关性：在T2DM患者中，铁蛋白水平与其他生物标志物如空腹血糖（FBS）、餐后2小时（2hpp）葡萄糖、同型半胱氨酸（Hcy）和尿酸（UA）之间存在显著相关性。在临床实践中的预测价值：该研究强调了γ-GT和铁蛋白作为具有成本效益且在临床实践中广泛应用的预测T2DM的检测方法的潜力

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Investigating the synergistic effects of gamma-glutamyl transferase with homocysteine, ferritin, and uric acid in patients with type II diabetes mellitus

Background and aim

Type 2 diabetes mellitus (T2DM) is a growing public health concern, with oxidative stress implicated in its onset and progression. This study evaluates the synergistic effects of gamma-glutamyl transferase (γ-GT) as a marker of oxidative stress with homocysteine (Hcy), uric acid (UA), and ferritin in T2DM patients compared to healthy individuals.

Material and methods

This case-control study included 200 participants, with 100 T2DM patients and 100 age- and sex-matched healthy individuals from the Ahvaz Pasteur pathology laboratory. Serum glucose and ferritin levels were measured using the Cobas E411 autoanalyzer (ECL method), and γ-GT, Hcy, and UA levels were measured using the Pentra C400 analyzer (photometric method). Data were analyzed using XLSTAT and SPSS software.

Results

A significant correlation was found between fasting blood sugar (FBS) and 2-h postprandial (2hpp) glucose levels with ferritin serum levels (P < 0.001, r = 0.419 and P = 0.002, r = 0.290, respectively), indicating ferritin's role in T2DM development. Ferritin levels were significantly related to γ-GT levels (P < 0.001, r = 0.359) and correlated with Hcy (P = 0.001, r = 0.336) and UA (P = 0.02, r = 0.218) in T2DM patients.

Conclusion

This study highlights the role of oxidative stress and the synergistic effects of γ-GT and ferritin in T2DM development, underscoring their potential as cost-effective and widely available markers for predicting T2DM in clinical practice. Unlike previous studies, which focused individually on oxidative stress markers, this research uniquely combines γ-GT with Hcy, UA, and ferritin, providing a comprehensive assessment of oxidative stress in T2DM patients.

Main points

1.
Role of Oxidative Stress in T2DM: The study investigates the role of oxidative stress markers, particularly gamma-glutamyl transferase (γ-GT) and ferritin, in the development of Type 2 diabetes mellitus (T2DM).
2.
Correlation with Other Biomarkers: Significant correlations were found between ferritin levels and other biomarkers such as fasting blood sugar (FBS), 2-hour postprandial (2hpp) glucose, homocysteine (Hcy), and uric acid (UA) in T2DM patients.
3.
Predictive Value in Clinical Practice: The study highlights the potential of γ-GT and ferritin as cost-effective and widely available assays for predicting T2DM in clinical practice

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来源期刊

Endocrine and Metabolic Science Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

84 days