ARID1A：人类妊娠的多种功能

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology Pub Date : 2025-02-03 DOI:10.1016/j.jri.2025.104448

Chongying Zhu , Bingquan Zhu , Shouying Xu , Lin Li , Yanhua Song , Chao Tang

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引用次数: 0

摘要

富含at的相互作用结构域分别包含蛋白1 A (ARID1A)，是SWItch/ sugar Non-Fermentable （SWI/SNF）染色质重塑复核的关键成员，已被证明在多种生理过程和疾病中发挥重要作用，包括女性生殖肿瘤，如卵巢癌和乳腺癌。除了关于ARID1A在癌症中的表达和功能的研究外，最近的研究结果阐明了它通过控制染色质重塑和转录因子募集来维持正常组织稳态和细胞分化的重要作用。在人类妊娠的背景下，ARID1A与几种妊娠相关并发症有关，包括妊娠糖尿病、先兆子痫和宫内生长受限。本文综述了目前关于ARID1A在妊娠中的作用的研究，强调了其作为这些并发症的生物标志物和治疗靶点的潜力。了解ARID1A在胎盘功能和妊娠相关疾病中的作用可能为开发新的诊断和治疗策略提供有价值的见解。

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ARID1A: Multiple functions in human pregnancy

AT-rich interacting domain containing respectively protein 1 A (ARID1A), a key member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, has been shown to play an important role in various physiological processes and diseases including female reproductive tumors, such as ovarian cancer and breast cancer. In addition to the studies regarding ARID1A expression and function in cancer, recent findings elucidate its important role in maintaining normal tissue homeostasis and cell differentiation by controlling chromatin remodeling and transcription factors recruitment. In the context of human pregnancy, ARID1A has been implicated in several pregnancy-related complications, including gestational diabetes, preeclampsia, and intrauterine growth restriction. This review examines the current research on the role of ARID1A in pregnancy, highlighting its potential as a biomarker and therapeutic target for these complications. Understanding the involvement of ARID1A in placental function and pregnancy-related disorders may provide valuable insights for the development of novel diagnostic and therapeutic strategies.

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来源期刊

Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.30

自引率

5.90%

发文量

162

审稿时长

10.6 weeks

期刊介绍： Affiliated with the European Society of Reproductive Immunology and with the International Society for Immunology of Reproduction The aim of the Journal of Reproductive Immunology is to provide the critical forum for the dissemination of results from high quality research in all aspects of experimental, animal and clinical reproductive immunobiology. This encompasses normal and pathological processes of: * Male and Female Reproductive Tracts * Gametogenesis and Embryogenesis * Implantation and Placental Development * Gestation and Parturition * Mammary Gland and Lactation.